FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2288832014> ?p ?o ?g. }

• W2288832014 endingPage "30" @default.
• W2288832014 startingPage "17" @default.
• W2288832014 abstract "Exposure of normal and tumor-derived cells to TGFβ results in different outcomes, depending on the regulation of key targets. The CDK inhibitor p27(Kip1) is one of these TGFβ targets and is essential for the TGFβ-induced cell cycle arrest. TGFβ treatment inhibits p27(Kip1) degradation and induces its nuclear translocation, through mechanisms that are still unknown. Recent evidences suggest that SUMOylation, a post-translational modification able to modulate the stability and subcellular localization of target proteins, critically modifies members of the TGFβ signaling pathway. Here, we demonstrate that p27(Kip1) is SUMOylated in response to TGFβ treatment. Using different p27(Kip1) point mutants, we identified lysine 134 (K134) as the residue modified by small ubiquitin-like modifier 1 (SUMO1) in response to TGFβ treatment. TGFβ-induced K134 SUMOylation increased protein stability and nuclear localization of both endogenous and exogenously expressed p27(Kip1). We observed that SUMOylation regulated p27(Kip1) binding to CDK2, thereby governing its nuclear proteasomal degradation through the phosphorylation of threonine 187. Importantly, p27(Kip1) SUMOylation was necessary for proper cell cycle exit following TGFβ treatment. These data indicate that SUMOylation is a novel regulatory mechanism that modulates p27(Kip1) function in response to TGFβ stimulation. Given the involvement of TGFβ signaling in cancer cell proliferation and invasion, our data may shed light on an important aspect of this pathway during tumor progression." @default.
• W2288832014 created "2016-06-24" @default.
• W2288832014 creator A5008340388 @default.
• W2288832014 creator A5015489236 @default.
• W2288832014 creator A5026382309 @default.
• W2288832014 creator A5037463401 @default.
• W2288832014 creator A5050473672 @default.
• W2288832014 creator A5056437767 @default.
• W2288832014 creator A5075072773 @default.
• W2288832014 creator A5075915926 @default.
• W2288832014 creator A5078815305 @default.
• W2288832014 creator A5086400503 @default.
• W2288832014 creator A5086775278 @default.
• W2288832014 date "2015-10-08" @default.
• W2288832014 modified "2023-10-16" @default.
• W2288832014 title "SUMOylation regulates p27^Kip1stability and localization in response to TGFβ" @default.
• W2288832014 cites W1521408518 @default.
• W2288832014 cites W1523693806 @default.
• W2288832014 cites W1549203021 @default.
• W2288832014 cites W1559573079 @default.
• W2288832014 cites W1834547194 @default.
• W2288832014 cites W1965049479 @default.
• W2288832014 cites W1971611931 @default.
• W2288832014 cites W1972449201 @default.
• W2288832014 cites W1974574293 @default.
• W2288832014 cites W1975324295 @default.
• W2288832014 cites W1979275431 @default.
• W2288832014 cites W1985901212 @default.
• W2288832014 cites W1996158740 @default.
• W2288832014 cites W1996695017 @default.
• W2288832014 cites W1996811697 @default.
• W2288832014 cites W1996916496 @default.
• W2288832014 cites W1998803989 @default.
• W2288832014 cites W2002898689 @default.
• W2288832014 cites W2013108773 @default.
• W2288832014 cites W2021457628 @default.
• W2288832014 cites W2038662992 @default.
• W2288832014 cites W2043591644 @default.
• W2288832014 cites W2043927273 @default.
• W2288832014 cites W2043968646 @default.
• W2288832014 cites W2044702943 @default.
• W2288832014 cites W2048228826 @default.
• W2288832014 cites W2049300045 @default.
• W2288832014 cites W2052032939 @default.
• W2288832014 cites W2052929547 @default.
• W2288832014 cites W2057861732 @default.
• W2288832014 cites W2070224555 @default.
• W2288832014 cites W2070349030 @default.
• W2288832014 cites W2073996456 @default.
• W2288832014 cites W2074455942 @default.
• W2288832014 cites W2074883939 @default.
• W2288832014 cites W2090411918 @default.
• W2288832014 cites W2093161405 @default.
• W2288832014 cites W2096283457 @default.
• W2288832014 cites W2110443750 @default.
• W2288832014 cites W2110768070 @default.
• W2288832014 cites W2111613650 @default.
• W2288832014 cites W2112658262 @default.
• W2288832014 cites W2129532370 @default.
• W2288832014 cites W2136128861 @default.
• W2288832014 cites W2136280424 @default.
• W2288832014 cites W2144948269 @default.
• W2288832014 cites W2151801593 @default.
• W2288832014 cites W2160654436 @default.
• W2288832014 cites W2163931326 @default.
• W2288832014 cites W2164764996 @default.
• W2288832014 cites W2201540170 @default.
• W2288832014 cites W2560367415 @default.
• W2288832014 cites W4232255240 @default.
• W2288832014 cites W4248693679 @default.
• W2288832014 cites W4376522323 @default.
• W2288832014 cites W95252060 @default.
• W2288832014 doi "https://doi.org/10.1093/jmcb/mjv056" @default.
• W2288832014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5943672" @default.
• W2288832014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26450989" @default.
• W2288832014 hasPublicationYear "2015" @default.
• W2288832014 type Work @default.
• W2288832014 sameAs 2288832014 @default.
• W2288832014 citedByCount "10" @default.
• W2288832014 countsByYear W22888320142016 @default.
• W2288832014 countsByYear W22888320142017 @default.
• W2288832014 countsByYear W22888320142018 @default.
• W2288832014 countsByYear W22888320142022 @default.
• W2288832014 countsByYear W22888320142023 @default.
• W2288832014 crossrefType "journal-article" @default.
• W2288832014 hasAuthorship W2288832014A5008340388 @default.
• W2288832014 hasAuthorship W2288832014A5015489236 @default.
• W2288832014 hasAuthorship W2288832014A5026382309 @default.
• W2288832014 hasAuthorship W2288832014A5037463401 @default.
• W2288832014 hasAuthorship W2288832014A5050473672 @default.
• W2288832014 hasAuthorship W2288832014A5056437767 @default.
• W2288832014 hasAuthorship W2288832014A5075072773 @default.
• W2288832014 hasAuthorship W2288832014A5075915926 @default.
• W2288832014 hasAuthorship W2288832014A5078815305 @default.
• W2288832014 hasAuthorship W2288832014A5086400503 @default.
• W2288832014 hasAuthorship W2288832014A5086775278 @default.
• W2288832014 hasBestOaLocation W22888320141 @default.
• W2288832014 hasConcept C104317684 @default.

• next