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- W2288883907 abstract "The developing preimplantation mammalian embryo undergoes transformation from a single cell to a system with multiple cell types during the variable preimplantation period. After fertilization, the embryo experiences a phase of cell division with little or no increase in size to form the morula stage embryo. The outer cells of the morula then form tight junctions, and following this compaction event blastulation occurs. The mammalian blastocyst consists of fundamentally two different cell types: those comprising the trophectoderm and those forming the inner cell mass (ICM). The degree of blastocyst expansion is species dependent. The development of trophectodermal polarity during embryogenesis is associated with the initiation of vectorial transport of various ions and metabolic substrates. Metabolic substrates that accumulate within embryonic cells are presumably utilized by the blastocyst to fulfill its energy requirements. Ion transport may be involved with the formation of blastocoel fluid and the subsequent increase in blastocoelic volume. The preimplantation embryo acquires mechanisms that are involved in the transport of large molecular substances, from the uterine lumen into the blastocoel. This chapter explains the transport mechanisms known to exist in developing mammalian embryos and the potential roles they may play in embryogenesis. There are details on ion transport—epithelial differentiation, Na + /K + -adenosine triphosphate (ATP)ase, ion channels, and intracellular ion concentrations. This chapter discusses fluid transport, sugar transport, protein transport, and amino acid transport. Development of the amiloride-sensitive Na + channel is independent of steroid hormones. Researchers have examined the question of cell lineage by peroxidase labeling cells of ICM or trophectoderm and then tracing the labeled cell's fate in other embryonic tissues. Their data suggested that some cells in the trophectoderm were derived from the ICM." @default.
- W2288883907 created "2016-06-24" @default.
- W2288883907 creator A5006781731 @default.
- W2288883907 creator A5008621245 @default.
- W2288883907 date "1991-01-01" @default.
- W2288883907 modified "2023-09-27" @default.
- W2288883907 title "Chapter 4 Ion and Solute Transport in Preimplantation Mammalian Embryos" @default.
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