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- W2288896612 abstract "Metabolomics is defined as “the non-biased quantification and identification of all metabolites present in a biological system” but in practice the term metabolomics is used in a rather broad sense and covers many different analytical methodologies. To address the challenges associated with metabolomics, an integrated analytical and data handling platform was developed that provides a chemo-centric global metabolomics analyses of biological systems. The analytical platform incorporates two separate UHPLC/MS/MS2 methods and a GC/MS method which increases the overall coverage of small molecules in a biological sample. The resulting MS and/or MS2 data are searched against an in-house generated authentic standard library which includes retention time, molecular mass to charge (m/z), preferred adducts and in-source fragment information as well as the associated MS fragmentation spectra for all biochemicals in the library. The library enables the rapid and accurate identification of the experimentally detected small molecules based on a multi-parameter match without need for time consuming further analysis. This integrated platform allows the robust, high-throughput collection and analysis of analytical data and accurately identifies a large number and broad spectrum of biochemicals thereby facilitating biochemical interpretation of metabolomic experiments." @default.
- W2288896612 created "2016-06-24" @default.
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- W2288896612 date "2010-04-01" @default.
- W2288896612 modified "2023-09-24" @default.
- W2288896612 title "Recent Advances in Metabolomics in Providing Mechanistic Insight and Discovering Biochemical Markers" @default.
- W2288896612 doi "https://doi.org/10.1096/fasebj.24.1_supplement.69.2" @default.
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