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- W2288896819 abstract "Diabetics have impaired vascular reactivity in the microcirculation; however, the time course of this impairment is unclear. Imaging of the retinal blood vessels provides unique insight into the microvasculature. PURPOSE To measure retinal diameter responses to vasoconstrictor and vasodilator stimuli in persons with type 2 diabetes compared to healthy controls. METHODS Retinal blood vessels were continuously imaged with the Dynamic Vessel Analyzer (Imedos, Jena, Germany) as six type 2 diabetics without retinopathy (57±7 yrs) and four healthy controls (53±10 yrs) inhaled 100% oxygen (5 min) and during flicker light-induced stimulation (5 min). RESULTS The diabetic compared to the control group had attenuated retinal vein vasoconstriction that was apparent within 2 minutes of hyperoxia (diabetics: −0.7±1.5%, −0.6±1.8%, −2.2±2.7%, −1.1±3.5% vs. controls: −2.9±1.2%, −5.4±0.9%, −7.5±1.6%, −8.4±0.8% at 2, 3, 4, and 5 min; P<0.05). Similar responses were observed in the retinal artery. Diabetics compared to controls also exhibited attenuated vasodilator responses (Artery: 1.1±1.0% vs. 8.6±5.3%; Vein: 2.4±3.2% vs. 7.2±2.6%; P<0.05). CONCLUSION Type 2 diabetics have both attenuated retinal vasodilator responses and early attenuated vasoconstrictor responses in which the mechanisms are unclear. Funded by Pennsylvania Department of Health using Tobacco CURE Funds." @default.
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- W2288896819 date "2010-04-01" @default.
- W2288896819 modified "2023-09-27" @default.
- W2288896819 title "Retinal Reactivity in Type 2 Diabetics" @default.
- W2288896819 doi "https://doi.org/10.1096/fasebj.24.1_supplement.981.6" @default.
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