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- W2288913919 endingPage "697" @default.
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- W2288913919 abstract "Abstract Defensins and cathelicidins are the two major families of mammalian anti-microbial proteins. They contribute to host, innate, anti-microbial defense by disrupting the integrity of the bacterial cell membrane. However, several members of the mammalian anti-microbial proteins including defensins and cathelicidins have been shown recently to have chemotactic effects on host cells. Human neutrophil α-defensins are chemotactic for resting, naïve CD45RA/CD4 T cells, CD8 T cells, and immature dendritic cells. Human β-defensins are also chemotactic for immature dendritic cells but induce the migration of memory CD45RO/CD4 T cells. In contrast, cathelicidin/LL-37 is chemotactic for neutrophils, monocytes, and T cells but not for dendritic cells. Thus, these anti-microbial peptides have distinct, host-target cell spectra. The chemotactic activities of human β-defensins and cathelicidin/LL-37 are mediated by human CC chemokine receptor 6 and formyl peptide receptor-like 1, respectively. The capacities of defensins and cathelicidins to mobilize various types of phagocytic leukocytes, immature dendritic cells, and lymphocytes, together with their other effects such as stimulating IL-8 production and mast cell degranulation, provide evidence for their participation in alerting, mobilizing, and amplifying innate and adaptive anti-microbial immunity of the host." @default.
- W2288913919 created "2016-06-24" @default.
- W2288913919 creator A5042240287 @default.
- W2288913919 creator A5042752501 @default.
- W2288913919 creator A5076554157 @default.
- W2288913919 date "2001-05-01" @default.
- W2288913919 modified "2023-10-15" @default.
- W2288913919 title "Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37)" @default.
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- W2288913919 doi "https://doi.org/10.1189/jlb.69.5.691" @default.
- W2288913919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11358975" @default.
- W2288913919 hasPublicationYear "2001" @default.
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