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- W2288934846 abstract "We reared wild-type flies in constant darkness for several generations, subculturing and handling them under a red safelight known not to affect Drosophila clock function or to be perceived visually by them. The locomotor activity rhythms of newly eclosed individuals were subsequently monitored in constant darkness, with no further exposure to light other than the far-red safelight. Only 23% of the flies had wild-type activity rhythms, and half of these had strong ultradian components, uncharacteristic of normally reared wild-type flies; an additional 10% had a novel phenotype: weak, short-period (20- to 22-h) circadian rhythms and relatively strong ultradian rhythms The remaining 68% were phenocopies of the period mutants, pero (52%) and perL (16%). The most common phenotype(35%) was pero-like, but apparently arrhythmic, lacking significant rhythmicity that could be discovered by our robust criteria; another 16% were pero-like with significant ultradian rhythms. The balance (16%) were phenocopies of perL, with relatively weak long-period rhythms and multiple ultradian rhythms. We hypothesize that exposure to light at some point in development acts to couple a population of ultradian oscillators into a composite circadian clock, and that the disruption of the rhythms seen in DD-reared animals is functionally identical to that found in animals mutant for the period gene." @default.
- W2288934846 created "2016-06-24" @default.
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- W2288934846 date "1989-05-01" @default.
- W2288934846 modified "2023-10-16" @default.
- W2288934846 title "Rearing Drosophila in Constant Darkness Produces Phenocopies of period Circadian Clock Mutants" @default.
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- W2288934846 doi "https://doi.org/10.1086/physzool.62.3.30157927" @default.
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