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- W2289000286 abstract "The small GTPase Rac1 has been implicated in the formation and dissemination of tumours. Upon activation by guanine nucleotide exchange factors (GEFs), Rac1 associates with a variety of proteins in the cell thereby regulating various functions, including cell migration. However, activation of Rac1 can lead to opposing migratory phenotypes raising the possibility of exacerbating tumour progression when targeting Rac1 in a clinical setting. This calls for the identification of factors that influence Rac1-driven cell motility. Here we show that Tiam1 and P-Rex1, two Rac GEFs, promote Rac1 anti- and pro-migratory signalling cascades, respectively, through regulating the Rac1 interactome. In particular, we demonstrate that P-Rex1 stimulates migration through enhancing the interaction between Rac1 and the actin-remodelling protein flightless-1 homologue, to modulate cell contraction in a RhoA-ROCK-independent manner." @default.
- W2289000286 created "2016-06-24" @default.
- W2289000286 creator A5004435609 @default.
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- W2289000286 date "2016-02-18" @default.
- W2289000286 modified "2023-10-15" @default.
- W2289000286 title "Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration" @default.
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- W2289000286 doi "https://doi.org/10.1038/ncomms10664" @default.
- W2289000286 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4759627" @default.
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- W2289000286 hasPublicationYear "2016" @default.
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