Matches in SemOpenAlex for { <https://semopenalex.org/work/W2289050356> ?p ?o ?g. }
- W2289050356 abstract "Curcumin, the major coloring principle of turmeric (Curcuma longa L.,Zingiberaceae), has a wide array of biological activities. It is soluble in organic solventslike acetone and dioxane. But, it is insoluble in water at acidic or neutral pH, which is adisadvantage for its use in water-based food products. Also, the molecule undergoesdegradation on exposure to light. Hence, newer strategies to prepare simple and safeadducts/derivatives are needed to overcome these drawbacks. In order to make curcuminwater-soluble, it is essential to attach to it a polar group or molecule that can imparthydrophilic nature to it. The major objectives of the present investigation weredevelopment of alternative, efficient and stereo-specific methods for obtaining specificderivatives of curcumin, their characterization, analysis and study of their bioactiveattributes. Approaches delineated in literature on curcumin derivatization are widerangingin nature. In the present study, particular emphasis was laid on preparation ofcurcumin derivatives with a sugar or an amino acid, as the resultant compounds would onhydrolysis afford natural molecules. Also, keeping in view the labile nature of curcumin,strategies evolved needed bringing about the derivatization under milder conditions andin higher yields. Thesis, describing the research results, includes five chapters. Chapterone covers literature on curcuminoids and their derivatives. Chapters 2, 3 and 4, describethe several synthetic methodologies developed in this study for selected curcuminderivatives. In Chapter 5, the in vitro antioxidant, antibacterial and antimutagenicproperties of all the curcumin derivatives prepared in the current work are presented." @default.
- W2289050356 created "2016-06-24" @default.
- W2289050356 creator A5046489162 @default.
- W2289050356 date "2009-01-01" @default.
- W2289050356 modified "2023-09-27" @default.
- W2289050356 title "Chemical approaches toward preparation of water-soluble curcumin derivatives" @default.
- W2289050356 cites W102553762 @default.
- W2289050356 cites W1258584912 @default.
- W2289050356 cites W1494121972 @default.
- W2289050356 cites W1522110495 @default.
- W2289050356 cites W1586405889 @default.
- W2289050356 cites W1667737342 @default.
- W2289050356 cites W1828339576 @default.
- W2289050356 cites W1847909360 @default.
- W2289050356 cites W1898811267 @default.
- W2289050356 cites W193486085 @default.
- W2289050356 cites W1963648801 @default.
- W2289050356 cites W1963822535 @default.
- W2289050356 cites W1968093540 @default.
- W2289050356 cites W1970500885 @default.
- W2289050356 cites W1970521986 @default.
- W2289050356 cites W1970929067 @default.
- W2289050356 cites W1972179974 @default.
- W2289050356 cites W1975708521 @default.
- W2289050356 cites W1976403584 @default.
- W2289050356 cites W1977319429 @default.
- W2289050356 cites W1977920395 @default.
- W2289050356 cites W1979445317 @default.
- W2289050356 cites W1982791593 @default.
- W2289050356 cites W1983746805 @default.
- W2289050356 cites W1987211751 @default.
- W2289050356 cites W1989828249 @default.
- W2289050356 cites W1990990931 @default.
- W2289050356 cites W1991178530 @default.
- W2289050356 cites W1991327193 @default.
- W2289050356 cites W1992436944 @default.
- W2289050356 cites W1993340740 @default.
- W2289050356 cites W1996017124 @default.
- W2289050356 cites W1996687962 @default.
- W2289050356 cites W1997149430 @default.
- W2289050356 cites W1999266834 @default.
- W2289050356 cites W1999873804 @default.
- W2289050356 cites W2000073304 @default.
- W2289050356 cites W2000474530 @default.
- W2289050356 cites W2000832550 @default.
- W2289050356 cites W2002833319 @default.
- W2289050356 cites W2003392863 @default.
- W2289050356 cites W2005156172 @default.
- W2289050356 cites W2005544180 @default.
- W2289050356 cites W2005970980 @default.
- W2289050356 cites W2007633892 @default.
- W2289050356 cites W2007880321 @default.
- W2289050356 cites W2008382270 @default.
- W2289050356 cites W2010203160 @default.
- W2289050356 cites W2010604146 @default.
- W2289050356 cites W2011657572 @default.
- W2289050356 cites W2011719781 @default.
- W2289050356 cites W2013252227 @default.
- W2289050356 cites W2015996393 @default.
- W2289050356 cites W2016999088 @default.
- W2289050356 cites W2019529286 @default.
- W2289050356 cites W2022180541 @default.
- W2289050356 cites W2022889851 @default.
- W2289050356 cites W2022941860 @default.
- W2289050356 cites W2024516071 @default.
- W2289050356 cites W2027588986 @default.
- W2289050356 cites W2028704769 @default.
- W2289050356 cites W2030304653 @default.
- W2289050356 cites W2030318070 @default.
- W2289050356 cites W2031434273 @default.
- W2289050356 cites W2031496016 @default.
- W2289050356 cites W2031647141 @default.
- W2289050356 cites W2032267608 @default.
- W2289050356 cites W2032510730 @default.
- W2289050356 cites W2032634050 @default.
- W2289050356 cites W2033203682 @default.
- W2289050356 cites W2033348335 @default.
- W2289050356 cites W2033431239 @default.
- W2289050356 cites W2033752864 @default.
- W2289050356 cites W2034302695 @default.
- W2289050356 cites W2034670010 @default.
- W2289050356 cites W2034673769 @default.
- W2289050356 cites W2035308484 @default.
- W2289050356 cites W2037596248 @default.
- W2289050356 cites W2037796790 @default.
- W2289050356 cites W2038234217 @default.
- W2289050356 cites W2038796248 @default.
- W2289050356 cites W2041804090 @default.
- W2289050356 cites W2042408205 @default.
- W2289050356 cites W2049751590 @default.
- W2289050356 cites W2051337581 @default.
- W2289050356 cites W2052002178 @default.
- W2289050356 cites W2054314428 @default.
- W2289050356 cites W2057436861 @default.
- W2289050356 cites W2057523433 @default.
- W2289050356 cites W2057960863 @default.
- W2289050356 cites W2059101719 @default.
- W2289050356 cites W2060416158 @default.
- W2289050356 cites W2061925446 @default.
- W2289050356 cites W2065769220 @default.