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- W2289070000 abstract "Background: Several studies demonstrate wide individual variability in the development and responses to treatment among patients with heart failure (HF). Part of this individual variability is due to genetic factors. Genetic polymorphisms (GP) are non-lethal genetic modifications found in ≥1% of the population that may be related both to prognoses and responses to treatment for HF. Many studies associate GP in adrenergic system, renin-angiotensin-aldosterone (SRAA) and in nitric oxide synthase enzyme (NOS) with various clinical outcomes in HF. However, most were small-scale studies that produced controversial findings. Moreover, the distribution of these polymorphisms among the Brazilian population is not well known. Objective: To evaluate the association of GP in the β-adrenergic system, SRAA and in NOS, through the clinical development and response to treatment of chronic stable HF patients. Methods: Among 800 chronic stable HF patients (200 with Chagas disease) with left ventricle ejection fraction (LVEF), <50% will be followed up for one year and the nine GP will be analyzed through polymerase chain reaction (PCR) and restricted fragment length polymorphism (RFLP) techniques that will be related to outcomes such as cardiac remodeling, functional capacity, hospitalization for HF, cardiovascular and total death. Additionally, the GP will be assessed in 200 healthy volunteers (control group). Conclusion: The GenetIC study will evaluate the association of the nine GP with the clinical development and responses to treatment among chronic stable HF patients with and without Chagas disease, in a follow-up lasting twelve months, in addition to assessing the GP in 200 healthy volunteers (control group)." @default.
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- W2289070000 date "2009-01-01" @default.
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- W2289070000 title "Estudo de Polimorfismos Genéticos na Insuficiência Cardíaca (GenetIC): delineamento do estudo e metodologia Study of Genetic Polymorphisms in Heart Failure (GenetIC): outline of the study and methodology" @default.
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