FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2289208429> ?p ?o ?g. }

• W2289208429 endingPage "427" @default.
• W2289208429 startingPage "414" @default.
• W2289208429 abstract "E2F transcription factors control the oscillating expression pattern of multiple target genes during the cell cycle. Activator E2Fs, E2F1-3, induce an upswing of E2F targets, which is essential for the G1-to-S phase transition, whereas atypical E2Fs, E2F7 and E2F8, mediate a downswing of the same targets during late S, G2, and M phases. Expression of atypical E2Fs is induced by E2F1-3, but it is unknown how atypical E2Fs are inactivated in a timely manner. Here, we demonstrate that E2F7 and E2F8 are substrates of the anaphase-promoting complex/cyclosome (APC/C). Removal of CDH1, or mutating the CDH1-interacting KEN boxes, stabilized E2F7/8 from anaphase onwards and during G1. Expressing KEN mutant E2F7 during G1 impairs S phase entry and eventually results in cell death. Furthermore, we show that E2F8, but not E2F7, interacts also with APC/C(C) (dc20). Importantly, atypical E2Fs can activate APC/C(C) (dh1) by repressing its inhibitors cyclin A, cyclin E, and Emi1. In conclusion, we discovered a feedback loop between atypical E2Fs and APC/C(C) (dh1), which ensures balanced expression of cell cycle genes and normal cell cycle progression." @default.
• W2289208429 created "2016-06-24" @default.
• W2289208429 creator A5003874489 @default.
• W2289208429 creator A5010265948 @default.
• W2289208429 creator A5020772605 @default.
• W2289208429 creator A5040059652 @default.
• W2289208429 creator A5055784121 @default.
• W2289208429 creator A5060499140 @default.
• W2289208429 creator A5064133308 @default.
• W2289208429 creator A5069612185 @default.
• W2289208429 creator A5075785888 @default.
• W2289208429 creator A5091597289 @default.
• W2289208429 date "2016-02-05" @default.
• W2289208429 modified "2023-10-08" @default.
• W2289208429 title "Feedback regulation between atypical E2Fs and <scp>APC</scp> / <scp> C ^C </scp> ^dh1 coordinates cell cycle progression" @default.
• W2289208429 cites W1483395792 @default.
• W2289208429 cites W1577577364 @default.
• W2289208429 cites W1885235228 @default.
• W2289208429 cites W1963937857 @default.
• W2289208429 cites W1970430170 @default.
• W2289208429 cites W1984252723 @default.
• W2289208429 cites W1991199800 @default.
• W2289208429 cites W1996435746 @default.
• W2289208429 cites W1998798121 @default.
• W2289208429 cites W2004042953 @default.
• W2289208429 cites W2005115966 @default.
• W2289208429 cites W2007943339 @default.
• W2289208429 cites W2013680732 @default.
• W2289208429 cites W2015141765 @default.
• W2289208429 cites W2016559686 @default.
• W2289208429 cites W2017413811 @default.
• W2289208429 cites W2020288787 @default.
• W2289208429 cites W2025571730 @default.
• W2289208429 cites W2027733273 @default.
• W2289208429 cites W2039412073 @default.
• W2289208429 cites W2044588337 @default.
• W2289208429 cites W2056040174 @default.
• W2289208429 cites W2060315657 @default.
• W2289208429 cites W2064113174 @default.
• W2289208429 cites W2064281414 @default.
• W2289208429 cites W2068278990 @default.
• W2289208429 cites W2077026062 @default.
• W2289208429 cites W2084833108 @default.
• W2289208429 cites W2091145752 @default.
• W2289208429 cites W2092836086 @default.
• W2289208429 cites W2095734738 @default.
• W2289208429 cites W2104049033 @default.
• W2289208429 cites W2104713031 @default.
• W2289208429 cites W2105672715 @default.
• W2289208429 cites W2112854488 @default.
• W2289208429 cites W2114070867 @default.
• W2289208429 cites W2121236039 @default.
• W2289208429 cites W2122511750 @default.
• W2289208429 cites W2128540871 @default.
• W2289208429 cites W2131520262 @default.
• W2289208429 cites W2132786809 @default.
• W2289208429 cites W2134609073 @default.
• W2289208429 cites W2136341530 @default.
• W2289208429 cites W2140037284 @default.
• W2289208429 cites W2140834174 @default.
• W2289208429 cites W2148531397 @default.
• W2289208429 cites W2154221478 @default.
• W2289208429 cites W2158990839 @default.
• W2289208429 cites W2164721923 @default.
• W2289208429 cites W2166374178 @default.
• W2289208429 cites W2340010069 @default.
• W2289208429 doi "https://doi.org/10.15252/embr.201540984" @default.
• W2289208429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4772983" @default.
• W2289208429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26882548" @default.
• W2289208429 hasPublicationYear "2016" @default.
• W2289208429 type Work @default.
• W2289208429 sameAs 2289208429 @default.
• W2289208429 citedByCount "23" @default.
• W2289208429 countsByYear W22892084292016 @default.
• W2289208429 countsByYear W22892084292017 @default.
• W2289208429 countsByYear W22892084292018 @default.
• W2289208429 countsByYear W22892084292019 @default.
• W2289208429 countsByYear W22892084292020 @default.
• W2289208429 countsByYear W22892084292021 @default.
• W2289208429 countsByYear W22892084292022 @default.
• W2289208429 countsByYear W22892084292023 @default.
• W2289208429 crossrefType "journal-article" @default.
• W2289208429 hasAuthorship W2289208429A5003874489 @default.
• W2289208429 hasAuthorship W2289208429A5010265948 @default.
• W2289208429 hasAuthorship W2289208429A5020772605 @default.
• W2289208429 hasAuthorship W2289208429A5040059652 @default.
• W2289208429 hasAuthorship W2289208429A5055784121 @default.
• W2289208429 hasAuthorship W2289208429A5060499140 @default.
• W2289208429 hasAuthorship W2289208429A5064133308 @default.
• W2289208429 hasAuthorship W2289208429A5069612185 @default.
• W2289208429 hasAuthorship W2289208429A5075785888 @default.
• W2289208429 hasAuthorship W2289208429A5091597289 @default.
• W2289208429 hasBestOaLocation W22892084292 @default.
• W2289208429 hasConcept C1491633281 @default.
• W2289208429 hasConcept C185592680 @default.
• W2289208429 hasConcept C29537977 @default.
• W2289208429 hasConcept C54355233 @default.
• W2289208429 hasConcept C86803240 @default.

• next