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• W2289215999 abstract "Nasopharyngeal carcinoma (NPC) has a high metastatic clinicopathological feature. As a carcinogen factor, N,N'-Dinitrosopiperazine (DNP) is involved in NPC metastasis, but its precise mechanism has not been fully elucidated. Herein, we showed that DNP promotes NPC metastasis through up-regulating anterior clusterin (CLU). DNP was found to increase CLU, matrix metalloproteinases (MMP) 9 and vascular endothelial growth factor (VEGF) expression and activity, further DNP-increased MMP-9 and VEGF expression was through up-regulating CLU. We also found that DNP increased the binding of CLU with MMP-9 or VEGF. DNP induced the motility and invasion of NPC cell, which was inhibited by siRNA-CLU. The clinical investigation showed that CLU, MMP-9 and VEGF were positively correlated with the tumor-node -metastasis (TNM) classification. These results indicate that DNP may promote NPC tumor metastasis through up-regulating CLU, MMP-9 and VEGF expression. Therefore, DNP-increased CLU expression may be an important factor of NPC-high metastasis, and CLU may serve as a biomarker for NPC metastasis." @default.
• W2289215999 created "2016-06-24" @default.
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• W2289215999 date "2015-12-24" @default.
• W2289215999 modified "2023-10-03" @default.
• W2289215999 title "Clusterin induced by N,N′-Dinitrosopiperazine is involved in nasopharyngeal carcinoma metastasis" @default.
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• W2289215999 doi "https://doi.org/10.18632/oncotarget.6750" @default.
• W2289215999 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4868705" @default.
• W2289215999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26716898" @default.
• W2289215999 hasPublicationYear "2015" @default.
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