Matches in SemOpenAlex for { <https://semopenalex.org/work/W2289343847> ?p ?o ?g. }
- W2289343847 abstract "Background: The aim of this retrospective study was to define clinical and pathologic features and prognostic factors among children and adolescents diagnosed with high-grade osteosarcoma of the extremities. Methods: A total of 73 patients younger than 18 years old diagnosed with primary osteosarcoma of the extremities between January 1998 and December 2013 were retrospectively evaluated. Prognostic factors such as age, gender, primary tumor site, alkaline phosphatase and lactate dehydrogenase levels, metastatic disease, pathological fracture, histological response and surgery type were analyzed to evaluate their effects on overall (OS) and event free survival (EFS). Results: At a median follow-up of 30 months (1.5-152), OS and EFS at 5 years was 64.5±8.1% and 48.5±8.7% for patients with localized disease; and 16.2±7.9% and 14.4±7.3% for patients with initial metastatic disease, respectively. In patients with localized disease, conservative surgery was performed on 22 of 46 patients (43.5%), and there was no significant difference in survival rates among patients who had conservative vs radical surgery (p=0.65). Although tumor size (>12cm) was significant prognostic factor in univariate analysis; multivariate analysis identified elevated levels of alkaline phosphatase (p=0.033) and poor response to neoadjuvant chemotherapy (p<0.001) only as independent prognostic factors. Age, histological type, pathological fracture and primary tumor site did not significantly affect prognosis. Conclusion: Initial elevated presence of alkaline phosphatase in serum and poor histological response after neoadjuvant chemotherapy were significant factors for unfavorable prognosis. It is necessary to optimize staging and treatment intensification to improve survival rates, especially among patients with metastasis at initial presentation." @default.
- W2289343847 created "2016-06-24" @default.
- W2289343847 creator A5010006283 @default.
- W2289343847 creator A5031919114 @default.
- W2289343847 creator A5056191448 @default.
- W2289343847 creator A5056953938 @default.
- W2289343847 creator A5062926989 @default.
- W2289343847 creator A5066904702 @default.
- W2289343847 creator A5073300869 @default.
- W2289343847 creator A5085307880 @default.
- W2289343847 date "2016-02-02" @default.
- W2289343847 modified "2023-09-26" @default.
- W2289343847 title "Analysis of Prognostic Factors in High-Grade Osteosarcoma of the Extremities in Children: A 15-Year Single-Institution Experience" @default.
- W2289343847 cites W1706026279 @default.
- W2289343847 cites W1854116296 @default.
- W2289343847 cites W1864208984 @default.
- W2289343847 cites W1902222293 @default.
- W2289343847 cites W1924934937 @default.
- W2289343847 cites W1944507750 @default.
- W2289343847 cites W1946181835 @default.
- W2289343847 cites W1954845453 @default.
- W2289343847 cites W1960987851 @default.
- W2289343847 cites W1962843207 @default.
- W2289343847 cites W1967605175 @default.
- W2289343847 cites W1971014305 @default.
- W2289343847 cites W1973532016 @default.
- W2289343847 cites W1975088474 @default.
- W2289343847 cites W1979453377 @default.
- W2289343847 cites W1981956631 @default.
- W2289343847 cites W1987662934 @default.
- W2289343847 cites W2003180293 @default.
- W2289343847 cites W2003557307 @default.
- W2289343847 cites W2060039734 @default.
- W2289343847 cites W2060688081 @default.
- W2289343847 cites W2062687868 @default.
- W2289343847 cites W2067883372 @default.
- W2289343847 cites W2073784198 @default.
- W2289343847 cites W2098002569 @default.
- W2289343847 cites W2112528206 @default.
- W2289343847 cites W2114840669 @default.
- W2289343847 cites W2116042827 @default.
- W2289343847 cites W2123745849 @default.
- W2289343847 cites W2124045959 @default.
- W2289343847 cites W2127748864 @default.
- W2289343847 cites W2142136189 @default.
- W2289343847 cites W2148077417 @default.
- W2289343847 cites W2152308356 @default.
- W2289343847 cites W2164449865 @default.
- W2289343847 cites W2222995977 @default.
- W2289343847 cites W2255287495 @default.
- W2289343847 cites W2283969964 @default.
- W2289343847 cites W2329218644 @default.
- W2289343847 cites W2560765535 @default.
- W2289343847 cites W27278923 @default.
- W2289343847 cites W324762618 @default.
- W2289343847 cites W4231356300 @default.
- W2289343847 cites W4246742253 @default.
- W2289343847 cites W70047781 @default.
- W2289343847 cites W1798345456 @default.
- W2289343847 doi "https://doi.org/10.3389/fonc.2016.00022" @default.
- W2289343847 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4745606" @default.
- W2289343847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26904501" @default.
- W2289343847 hasPublicationYear "2016" @default.
- W2289343847 type Work @default.
- W2289343847 sameAs 2289343847 @default.
- W2289343847 citedByCount "33" @default.
- W2289343847 countsByYear W22893438472016 @default.
- W2289343847 countsByYear W22893438472017 @default.
- W2289343847 countsByYear W22893438472018 @default.
- W2289343847 countsByYear W22893438472019 @default.
- W2289343847 countsByYear W22893438472020 @default.
- W2289343847 countsByYear W22893438472021 @default.
- W2289343847 countsByYear W22893438472022 @default.
- W2289343847 countsByYear W22893438472023 @default.
- W2289343847 crossrefType "journal-article" @default.
- W2289343847 hasAuthorship W2289343847A5010006283 @default.
- W2289343847 hasAuthorship W2289343847A5031919114 @default.
- W2289343847 hasAuthorship W2289343847A5056191448 @default.
- W2289343847 hasAuthorship W2289343847A5056953938 @default.
- W2289343847 hasAuthorship W2289343847A5062926989 @default.
- W2289343847 hasAuthorship W2289343847A5066904702 @default.
- W2289343847 hasAuthorship W2289343847A5073300869 @default.
- W2289343847 hasAuthorship W2289343847A5085307880 @default.
- W2289343847 hasBestOaLocation W22893438471 @default.
- W2289343847 hasConcept C126322002 @default.
- W2289343847 hasConcept C141071460 @default.
- W2289343847 hasConcept C142724271 @default.
- W2289343847 hasConcept C143998085 @default.
- W2289343847 hasConcept C144301174 @default.
- W2289343847 hasConcept C146357865 @default.
- W2289343847 hasConcept C151730666 @default.
- W2289343847 hasConcept C160160445 @default.
- W2289343847 hasConcept C167135981 @default.
- W2289343847 hasConcept C181199279 @default.
- W2289343847 hasConcept C185592680 @default.
- W2289343847 hasConcept C207886595 @default.
- W2289343847 hasConcept C2776694085 @default.
- W2289343847 hasConcept C2777318727 @default.
- W2289343847 hasConcept C2777760704 @default.
- W2289343847 hasConcept C2777969384 @default.