FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2289403763> ?p ?o ?g. }

• W2289403763 endingPage "776" @default.
• W2289403763 startingPage "764" @default.
• W2289403763 abstract "The cellular proteolytic machinery orchestrates protein turnover and regulates several key biological processes. This study addresses the roles of Lon, a major ATP-dependent protease, in modulating the responses of Escherichia coli strain MG1655 to low and high amounts of sodium salicyclate (NaSal), a widely used clinically relevant analgesic. NaSal affects several bacterial responses, including growth and resistance to multiple antibiotics. The loss of lon reduces growth in response to high, but not low, amounts of NaSal. From amongst a panel of Lon substrates, MarA was identified to be the downstream target of Lon. Thus, stabilization of MarA in the absence of lon lowers growth of the strain in the presence of higher amounts of NaSal. The steady-state transcript levels of marA and its target genes, acrA, acrB and tolC, are higher in the Δlon strain compared with the WT strain. Consequently, the resistance to antibiotics, e.g. tetracycline and nalidixic acid, is enhanced in Δlon in a marA-dependent manner. Furthermore, the target genes of MarA, i.e. acrB and tolC, are responsible for NaSal-mediated antibiotic resistance. Studies using atomic force microscopy demonstrated that ciprofloxacin led to greater cell filamentation, which is lower in the Δlon strain due to higher levels of MarA. Overall, this study delineates the roles of Lon protease, its substrate MarA and downstream targets of MarA, e.g. acrB and tolC, during NaSal-mediated growth reduction and antibiotic resistance. The implications of these observations in the adaptation of E. coli under different environmental conditions are discussed." @default.
• W2289403763 created "2016-06-24" @default.
• W2289403763 creator A5008256897 @default.
• W2289403763 creator A5029693326 @default.
• W2289403763 creator A5032476255 @default.
• W2289403763 creator A5056935185 @default.
• W2289403763 creator A5058711049 @default.
• W2289403763 creator A5084068974 @default.
• W2289403763 date "2016-05-01" @default.
• W2289403763 modified "2023-10-11" @default.
• W2289403763 title "Roles of Lon protease and its substrate MarA during sodium salicylate-mediated growth reduction and antibiotic resistance in Escherichia coli" @default.
• W2289403763 cites W1501334198 @default.
• W2289403763 cites W1516819142 @default.
• W2289403763 cites W1542936268 @default.
• W2289403763 cites W1803761491 @default.
• W2289403763 cites W1834019024 @default.
• W2289403763 cites W1897782729 @default.
• W2289403763 cites W1908114653 @default.
• W2289403763 cites W1971425619 @default.
• W2289403763 cites W1975262722 @default.
• W2289403763 cites W1982204394 @default.
• W2289403763 cites W1991265385 @default.
• W2289403763 cites W1995205705 @default.
• W2289403763 cites W2009646503 @default.
• W2289403763 cites W2011324244 @default.
• W2289403763 cites W2015022820 @default.
• W2289403763 cites W2017495709 @default.
• W2289403763 cites W2026227829 @default.
• W2289403763 cites W2038260155 @default.
• W2289403763 cites W2050627714 @default.
• W2289403763 cites W2051363032 @default.
• W2289403763 cites W2053536354 @default.
• W2289403763 cites W2054351525 @default.
• W2289403763 cites W2081594548 @default.
• W2289403763 cites W2090018161 @default.
• W2289403763 cites W2091108486 @default.
• W2289403763 cites W2101677900 @default.
• W2289403763 cites W2106461141 @default.
• W2289403763 cites W2109214045 @default.
• W2289403763 cites W2111357564 @default.
• W2289403763 cites W2111967267 @default.
• W2289403763 cites W2116137883 @default.
• W2289403763 cites W2122510025 @default.
• W2289403763 cites W2126887640 @default.
• W2289403763 cites W2132771466 @default.
• W2289403763 cites W2143810817 @default.
• W2289403763 cites W2149820656 @default.
• W2289403763 cites W2156228464 @default.
• W2289403763 cites W2157664391 @default.
• W2289403763 cites W2157688183 @default.
• W2289403763 cites W2161899289 @default.
• W2289403763 cites W2163999241 @default.
• W2289403763 cites W2164846660 @default.
• W2289403763 cites W2167556437 @default.
• W2289403763 cites W2322957911 @default.
• W2289403763 cites W38763105 @default.
• W2289403763 doi "https://doi.org/10.1099/mic.0.000271" @default.
• W2289403763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26944926" @default.
• W2289403763 hasPublicationYear "2016" @default.
• W2289403763 type Work @default.
• W2289403763 sameAs 2289403763 @default.
• W2289403763 citedByCount "29" @default.
• W2289403763 countsByYear W22894037632017 @default.
• W2289403763 countsByYear W22894037632018 @default.
• W2289403763 countsByYear W22894037632019 @default.
• W2289403763 countsByYear W22894037632020 @default.
• W2289403763 countsByYear W22894037632021 @default.
• W2289403763 countsByYear W22894037632022 @default.
• W2289403763 countsByYear W22894037632023 @default.
• W2289403763 crossrefType "journal-article" @default.
• W2289403763 hasAuthorship W2289403763A5008256897 @default.
• W2289403763 hasAuthorship W2289403763A5029693326 @default.
• W2289403763 hasAuthorship W2289403763A5032476255 @default.
• W2289403763 hasAuthorship W2289403763A5056935185 @default.
• W2289403763 hasAuthorship W2289403763A5058711049 @default.
• W2289403763 hasAuthorship W2289403763A5084068974 @default.
• W2289403763 hasBestOaLocation W22894037631 @default.
• W2289403763 hasConcept C104317684 @default.
• W2289403763 hasConcept C105702510 @default.
• W2289403763 hasConcept C17741926 @default.
• W2289403763 hasConcept C181199279 @default.
• W2289403763 hasConcept C182220744 @default.
• W2289403763 hasConcept C200082930 @default.
• W2289403763 hasConcept C2775876089 @default.
• W2289403763 hasConcept C2776714187 @default.
• W2289403763 hasConcept C2778022156 @default.
• W2289403763 hasConcept C2778512257 @default.
• W2289403763 hasConcept C2780923616 @default.
• W2289403763 hasConcept C501593827 @default.
• W2289403763 hasConcept C523546767 @default.
• W2289403763 hasConcept C54355233 @default.
• W2289403763 hasConcept C547475151 @default.
• W2289403763 hasConcept C55493867 @default.
• W2289403763 hasConcept C86803240 @default.
• W2289403763 hasConcept C89423630 @default.
• W2289403763 hasConcept C94665300 @default.
• W2289403763 hasConceptScore W2289403763C104317684 @default.
• W2289403763 hasConceptScore W2289403763C105702510 @default.

• next