FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2289408112> ?p ?o ?g. }

• W2289408112 abstract "Nuclear receptors (NR) act as an integrated conduit for environmental and hormonal signals to govern genomic responses, which relate to cell fate decisions. We review how their integrated actions with each other, shared co-factors and other transcription factors are disrupted in cancer. Steroid hormone nuclear receptors are oncogenic drivers in breast and prostate cancer and blockade of signaling is a major therapeutic goal. By contrast to blockade of receptors, in other cancers enhanced receptor function is attractive, as illustrated initially with targeting of retinoic acid receptors in leukemia. In the post-genomic era large consortia, such as The Cancer Genome Atlas, have developed a remarkable volume of genomic data with which to examine multiple aspects of nuclear receptor status in a pan-cancer manner. Therefore to extend the review of NR function we have also undertaken bioinformatics analyses of NR expression in over 3000 tumors, spread across six different tumor types (bladder, breast, colon, head and neck, liver and prostate). Specifically, to ask how the NR expression was distorted (altered expression, mutation and CNV) we have applied bootstrapping approaches to simulate data for comparison, and also compared these NR findings to 12 other transcription factor families. Nuclear receptors were uniquely and uniformly downregulated across all six tumor types, more than predicted by chance. These approaches also revealed that each tumor type had a specific NR expression profile but these were most similar between breast and prostate cancer. Some NRs were down-regulated in at least five tumor types (e.g. NR3C2/MR and NR5A2/LRH-1)) whereas others were uniquely down-regulated in one tumor (e.g. NR1B3/RARG). The downregulation was not driven by copy number variation or mutation and epigenetic mechanisms maybe responsible for the altered nuclear receptor expression." @default.
• W2289408112 created "2016-06-24" @default.
• W2289408112 creator A5004959346 @default.
• W2289408112 creator A5028515700 @default.
• W2289408112 date "2015-01-01" @default.
• W2289408112 modified "2023-10-13" @default.
• W2289408112 title "Pan-Cancer Analyses of the Nuclear Receptor Superfamily" @default.
• W2289408112 cites W1486948598 @default.
• W2289408112 cites W1504527734 @default.
• W2289408112 cites W1507622309 @default.
• W2289408112 cites W1519834766 @default.
• W2289408112 cites W1533942137 @default.
• W2289408112 cites W1550565578 @default.
• W2289408112 cites W1554600230 @default.
• W2289408112 cites W1567018500 @default.
• W2289408112 cites W1670745072 @default.
• W2289408112 cites W1748436622 @default.
• W2289408112 cites W188006079 @default.
• W2289408112 cites W1904308459 @default.
• W2289408112 cites W1914243963 @default.
• W2289408112 cites W1919901534 @default.
• W2289408112 cites W1964464520 @default.
• W2289408112 cites W1967099832 @default.
• W2289408112 cites W1967927604 @default.
• W2289408112 cites W1968144869 @default.
• W2289408112 cites W1968343445 @default.
• W2289408112 cites W1968682237 @default.
• W2289408112 cites W1970956961 @default.
• W2289408112 cites W1972752736 @default.
• W2289408112 cites W1974414866 @default.
• W2289408112 cites W1974555331 @default.
• W2289408112 cites W1976992030 @default.
• W2289408112 cites W1977704003 @default.
• W2289408112 cites W1978243004 @default.
• W2289408112 cites W1979946545 @default.
• W2289408112 cites W1981491540 @default.
• W2289408112 cites W1985714890 @default.
• W2289408112 cites W1986190328 @default.
• W2289408112 cites W1986553481 @default.
• W2289408112 cites W1987289975 @default.
• W2289408112 cites W1987709756 @default.
• W2289408112 cites W1988789058 @default.
• W2289408112 cites W1988951534 @default.
• W2289408112 cites W1989367833 @default.
• W2289408112 cites W1992891812 @default.
• W2289408112 cites W1997673869 @default.
• W2289408112 cites W2004966039 @default.
• W2289408112 cites W2006181492 @default.
• W2289408112 cites W2006920000 @default.
• W2289408112 cites W2011202006 @default.
• W2289408112 cites W2011313635 @default.
• W2289408112 cites W2011752009 @default.
• W2289408112 cites W2018327162 @default.
• W2289408112 cites W2018328431 @default.
• W2289408112 cites W2019796661 @default.
• W2289408112 cites W2020646112 @default.
• W2289408112 cites W2020990564 @default.
• W2289408112 cites W2030321647 @default.
• W2289408112 cites W2030751364 @default.
• W2289408112 cites W2038411989 @default.
• W2289408112 cites W2038970025 @default.
• W2289408112 cites W2040677781 @default.
• W2289408112 cites W2042874875 @default.
• W2289408112 cites W2043005530 @default.
• W2289408112 cites W2044702943 @default.
• W2289408112 cites W2045467665 @default.
• W2289408112 cites W2048350099 @default.
• W2289408112 cites W2051025382 @default.
• W2289408112 cites W2053433605 @default.
• W2289408112 cites W2053516868 @default.
• W2289408112 cites W2055627657 @default.
• W2289408112 cites W2056048638 @default.
• W2289408112 cites W2062465243 @default.
• W2289408112 cites W2064293531 @default.
• W2289408112 cites W2066677392 @default.
• W2289408112 cites W2072069303 @default.
• W2289408112 cites W2072457049 @default.
• W2289408112 cites W2074369446 @default.
• W2289408112 cites W2076154138 @default.
• W2289408112 cites W2077498188 @default.
• W2289408112 cites W2080683349 @default.
• W2289408112 cites W2080748037 @default.
• W2289408112 cites W2084574319 @default.
• W2289408112 cites W2087888470 @default.
• W2289408112 cites W2088617756 @default.
• W2289408112 cites W2090355587 @default.
• W2289408112 cites W2091116852 @default.
• W2289408112 cites W2091929104 @default.
• W2289408112 cites W2094239034 @default.
• W2289408112 cites W2096283457 @default.
• W2289408112 cites W2097689792 @default.
• W2289408112 cites W2098211567 @default.
• W2289408112 cites W2098236847 @default.
• W2289408112 cites W2098558937 @default.
• W2289408112 cites W2101093278 @default.
• W2289408112 cites W2101909833 @default.
• W2289408112 cites W2104748610 @default.
• W2289408112 cites W2105069705 @default.
• W2289408112 cites W2107633226 @default.
• W2289408112 cites W2109388713 @default.

• next