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• W2289498718 abstract "Purpose: This study prepared three structurally related zinc–dipicolylamine (ZnDPA) tracers with [ 111 In] labels and conducted biodistribution and single-photon emission computed tomography/ computed tomography (SPECT/CT) imaging studies of a mouse leg infection model. Procedures: Two monovalent tracers, ZnDPA-[ 111 In]DTPA and ZnDPA-[ 111 In]DOTA, each with a single zinc–dipicolylamine targeting unit, and a divalent tracer, Bis(ZnDPA)-[ 111 In]DTPA, with two zinc–dipicolylamine units were prepared. Organ biodistribution and SPECT and CT imaging studies were performed on living mice with a leg infection created by injection of clinically relevant Gram positive Streptococcus pyogenes. Fluorescent and luminescent Eu 3+ -labeled versions of these tracers were also prepared and used to measure relative affinity for the exterior membrane surface of bacterial cells and mimics of healthy mammalian cells. Results: All three 111 In-labeled radiotracers were prepared with a radiopurity of 990 %. The biodistribution studies showed that the two monovalent tracers were cleared from the body through the liver and kidney, with retained percentage injected dose for all organs of G 8%a t 20 h and infected leg target to non-target ratio (T/NT) ratio of ≤3.0. Clearance of the divalent tracer from the bloodstream was slower and primarily through the liver, with a retained percentage injected dose for all organs G37 % at 20 h and T/NT ratio rising to 6.2 after 20 h. The SPECT/CT imaging indicated the same large difference in tracer pharmacokinetics and higher accumulation of the divalent tracer at the site of infection. Conclusions: All three [ 111 In]-ZnDPA tracers selectively targeted the site of a clinically relevant mouse infection model that could not be discerned by visual external inspection of the living animal. The highest target selectivity, observed with a divalent tracer equipped with two zinc–dipicolylamine targeting units, compares quite favorably with the imaging selectivities previously reported for other nuclear tracers that target bacterial cell surfaces. The tracer pharmacokinetics depended heavily on tracer molecular structure suggesting that it may be possible to rapidly fine tune the structural properties for optimized in vivo imaging performance and clinical translation." @default.
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• W2289498718 date "2015-01-01" @default.
• W2289498718 modified "2023-09-23" @default.
• W2289498718 title "RESEARCH ARTICLE Evaluation of ( 111 In)-Labeled Zinc-Dipicolylamine Tracers for SPECT Imaging of Bacterial Infection" @default.
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