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- W2289587400 abstract "Background: The extent and quality of the immune response to orally applied allergens may critically depend on the precise site of uptake at the intestinal mucosa. Objective: The aim of this study was to construct allergen vehicles optimized for oral allergen immunotherapy. Methods: By using a murine model, we examined the immunomodulatory effect of birch pollen proteins entrapped in poly(D,L-lactide-co-glycolide) microspheres, which were specifically targeted to enterocytes or to M cells, in an ongoing TH2 response. BALB/c mice express different carbohydrates on these 2 cell types. To target the sialylic residues on murine enterocytes, we functionalized microspheres with wheat germ agglutinin (WGA) and, to target a-L-fucose on M cells, with a lectin from Aleuria aurantia (AAL), the orange peel mushroom. Results: Both WGA and AAL functionalization enhanced binding to human Caco2 cells substantially, which express sialylic and, as carcinoma cells, also a-L-fucose residues. Different groups of BALB/c mice were first sensitized to birch pollen and subsequently fed with birch pollen-loaded" @default.
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- W2289587400 date "2004-01-01" @default.
- W2289587400 modified "2023-09-27" @default.
- W2289587400 title "Original articles M cell targeting with Aleuria aurantia lectin as a novel approach for oral allergen immunotherapy" @default.
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