FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2289615308> ?p ?o ?g. }

• W2289615308 endingPage "1229" @default.
• W2289615308 startingPage "1225" @default.
• W2289615308 abstract "The identification of key factors accounting for the health benefits of metabolic surgery is a research priority, as it may help design a medical therapy mimicking this powerful surgical tool. Because of its well-known effects on glucose metabolism and appetite, amongst the several proposed factors, glucagon-like peptide-1 (GLP-1) has been the most extensively evaluated. A large number of association studies have been reported suggesting that the striking changes in GLP-1 after Roux-en-Y gastric bypass and sleeve gastrectomy play a role in the metabolic benefits associated with these surgical techniques. In this review article, we challenge this view. Studies in humans using the specific GLP-1 receptor antagonist exendin 9-39 or the nonspecific inhibitor of GLP-1 secretion octreotide, as well as data derived from genetically engineered mouse models, provide strong evidence that although GLP-1 retains its physiologic role, it is not the cause of the amelioration of glucose tolerance or sustained weight loss after Roux-en-Y gastric bypass or sleeve gastrectomy. It is unlikely that “medical metabolic surgery” will be based on a single component. Importantly, the scrutiny of GLP-1 as candidate has taught us studies beyond association are required to thoroughly assess whether any of the additionally proposed mediators should be part of the cocktail of factors that could medically mimic metabolic surgery." @default.
• W2289615308 created "2016-06-24" @default.
• W2289615308 creator A5018451703 @default.
• W2289615308 creator A5059482218 @default.
• W2289615308 creator A5063203479 @default.
• W2289615308 date "2016-07-01" @default.
• W2289615308 modified "2023-10-18" @default.
• W2289615308 title "GLP-1 is not the key mediator of the health benefits of metabolic surgery" @default.
• W2289615308 cites W1492956228 @default.
• W2289615308 cites W1900087273 @default.
• W2289615308 cites W1927219547 @default.
• W2289615308 cites W1975238467 @default.
• W2289615308 cites W1979317748 @default.
• W2289615308 cites W1982379476 @default.
• W2289615308 cites W1986733661 @default.
• W2289615308 cites W2009646834 @default.
• W2289615308 cites W2015080685 @default.
• W2289615308 cites W2018619654 @default.
• W2289615308 cites W2022068139 @default.
• W2289615308 cites W2029355071 @default.
• W2289615308 cites W2032563883 @default.
• W2289615308 cites W2055711839 @default.
• W2289615308 cites W2057580954 @default.
• W2289615308 cites W2059428929 @default.
• W2289615308 cites W2061779076 @default.
• W2289615308 cites W2068157421 @default.
• W2289615308 cites W2070771474 @default.
• W2289615308 cites W2076780346 @default.
• W2289615308 cites W2077696851 @default.
• W2289615308 cites W2079737026 @default.
• W2289615308 cites W2083514058 @default.
• W2289615308 cites W2084309435 @default.
• W2289615308 cites W2084948079 @default.
• W2289615308 cites W2095971031 @default.
• W2289615308 cites W2097159083 @default.
• W2289615308 cites W2101709187 @default.
• W2289615308 cites W2118890238 @default.
• W2289615308 cites W2119568544 @default.
• W2289615308 cites W2132275840 @default.
• W2289615308 cites W2137892791 @default.
• W2289615308 cites W2145233788 @default.
• W2289615308 cites W2146737709 @default.
• W2289615308 cites W2151025825 @default.
• W2289615308 cites W2166561625 @default.
• W2289615308 cites W2170358620 @default.
• W2289615308 cites W2170738901 @default.
• W2289615308 cites W2193419945 @default.
• W2289615308 doi "https://doi.org/10.1016/j.soard.2016.02.029" @default.
• W2289615308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27313195" @default.
• W2289615308 hasPublicationYear "2016" @default.
• W2289615308 type Work @default.
• W2289615308 sameAs 2289615308 @default.
• W2289615308 citedByCount "23" @default.
• W2289615308 countsByYear W22896153082016 @default.
• W2289615308 countsByYear W22896153082017 @default.
• W2289615308 countsByYear W22896153082018 @default.
• W2289615308 countsByYear W22896153082019 @default.
• W2289615308 countsByYear W22896153082020 @default.
• W2289615308 countsByYear W22896153082021 @default.
• W2289615308 countsByYear W22896153082022 @default.
• W2289615308 countsByYear W22896153082023 @default.
• W2289615308 crossrefType "journal-article" @default.
• W2289615308 hasAuthorship W2289615308A5018451703 @default.
• W2289615308 hasAuthorship W2289615308A5059482218 @default.
• W2289615308 hasAuthorship W2289615308A5063203479 @default.
• W2289615308 hasConcept C121608353 @default.
• W2289615308 hasConcept C126322002 @default.
• W2289615308 hasConcept C134018914 @default.
• W2289615308 hasConcept C141071460 @default.
• W2289615308 hasConcept C177713679 @default.
• W2289615308 hasConcept C2107291 @default.
• W2289615308 hasConcept C2776398474 @default.
• W2289615308 hasConcept C2777180221 @default.
• W2289615308 hasConcept C2778586554 @default.
• W2289615308 hasConcept C2779400339 @default.
• W2289615308 hasConcept C2780470880 @default.
• W2289615308 hasConcept C3019402062 @default.
• W2289615308 hasConcept C511355011 @default.
• W2289615308 hasConcept C544821477 @default.
• W2289615308 hasConcept C555293320 @default.
• W2289615308 hasConcept C60644358 @default.
• W2289615308 hasConcept C71924100 @default.
• W2289615308 hasConcept C86803240 @default.
• W2289615308 hasConceptScore W2289615308C121608353 @default.
• W2289615308 hasConceptScore W2289615308C126322002 @default.
• W2289615308 hasConceptScore W2289615308C134018914 @default.
• W2289615308 hasConceptScore W2289615308C141071460 @default.
• W2289615308 hasConceptScore W2289615308C177713679 @default.
• W2289615308 hasConceptScore W2289615308C2107291 @default.
• W2289615308 hasConceptScore W2289615308C2776398474 @default.
• W2289615308 hasConceptScore W2289615308C2777180221 @default.
• W2289615308 hasConceptScore W2289615308C2778586554 @default.
• W2289615308 hasConceptScore W2289615308C2779400339 @default.
• W2289615308 hasConceptScore W2289615308C2780470880 @default.
• W2289615308 hasConceptScore W2289615308C3019402062 @default.
• W2289615308 hasConceptScore W2289615308C511355011 @default.
• W2289615308 hasConceptScore W2289615308C544821477 @default.
• W2289615308 hasConceptScore W2289615308C555293320 @default.

• next