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• W2289619544 abstract "Research Article1 February 1996free access A multicopy suppressor of a cell cycle defect in S. pombe encodes a heat shock-inducible 40 kDa cyclophilin-like protein. R. Weisman R. Weisman Department of Molecular Microbiology, University of Tel-Aviv, Israel. Search for more papers by this author J. Creanor J. Creanor Department of Molecular Microbiology, University of Tel-Aviv, Israel. Search for more papers by this author P. Fantes P. Fantes Department of Molecular Microbiology, University of Tel-Aviv, Israel. Search for more papers by this author R. Weisman R. Weisman Department of Molecular Microbiology, University of Tel-Aviv, Israel. Search for more papers by this author J. Creanor J. Creanor Department of Molecular Microbiology, University of Tel-Aviv, Israel. Search for more papers by this author P. Fantes P. Fantes Department of Molecular Microbiology, University of Tel-Aviv, Israel. Search for more papers by this author Author Information R. Weisman1, J. Creanor1 and P. Fantes1 1Department of Molecular Microbiology, University of Tel-Aviv, Israel. The EMBO Journal (1996)15:447-456https://doi.org/10.1002/j.1460-2075.1996.tb00377.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Cyclophilins are peptidyl-prolyl cis-trans isomerases (PPIases) which have been implicated in intracellular protein folding, transport and assembly. Cyclophilins are also known as the intracellular receptors for the immunosuppressive drug cyclosporin A (CsA). The most common type of cyclophilins are the 18 kDa cytosolic proteins containing only the highly conserved core domain for PPIase and CsA binding activities. The wis2+ gene of the fission yeast Schizosaccharomyces pombe was isolated as a multicopy suppressor of wee1–50 cdc25–22 win1–1, a triple mutant strain which exhibits a cell cycle defect phenotype. Sequence analysis of wis2+ reveals that it encodes a 40 kDa cyclophilin-like protein, homologous to the mammalian cyclophilin 40. The 18 kDa cyclophilin domain (CyP-18) of wis2 is followed by a C-terminal region of 188 amino acids. The C-terminal region of wis2 is essential for suppression of the triple mutant defect. Furthermore this region of the protein is able to confer suppression activity on the 18 kDa S.pombe cyclophilin, cyp1, since a hybrid protein consisting of an 18 kDa S.pombe cyclophilin (cyp1) fused to the C-terminus of wis2 shows suppression activity. We also demonstrate that the level of wis2+ mRNA increases 10- to 20-fold upon heat shock of S.pombe cells suggesting a role for wis2+ in the heat-shock response. Previous ArticleNext Article Volume 15Issue 31 February 1996In this issue RelatedDetailsLoading ..." @default.
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• W2289619544 title "A multicopy suppressor of a cell cycle defect in S. pombe encodes a heat shock-inducible 40 kDa cyclophilin-like protein." @default.
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• W2289619544 doi "https://doi.org/10.1002/j.1460-2075.1996.tb00377.x" @default.
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