FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2289623110> ?p ?o ?g. }

• W2289623110 endingPage "786" @default.
• W2289623110 startingPage "778" @default.
• W2289623110 abstract "Metabotropic glutamate (mGlu), Ca²⁺-sensing, γ-aminobutyric acid_B, and a large number of pheromone receptors constitute a peculiar family of G protein-coupled receptors. They possess a large extracellular domain that has been proposed to constitute their ligand binding domain. The aim of the current study was to examine whether this large ligand binding domain had any influence on the G protein-coupling selectivity of the receptor, and vice versa. We chose mGlu receptors, which are classified into three groups according to their sequence homology and pharmacology, as representatives of this receptor family. To define a G protein-coupling profile for these receptors, we used a set of exogenous phospholipase C-activating G proteins in the same way that synthetic ligands are used to define agonist and antagonist pharmacological profiles. This set includes G_α15, G_α16, G_αq, and chimeric G_αq proteins with the last few amino acids of either G_αi2 (G_αqi), G_αo(G_αqo), or G_αz (G_αqz). Cotransfection of mGlu receptors with these G proteins and examination of their coupling to phospholipase C revealed that group I, II, and III receptors have distinct G protein-coupling profiles. By swapping the extracellular domains of the most distantly related mGlu receptors (the rat group I mGlu1a and the <i>Drosophila melanogaster</i> group II DmGluA receptors), we show that the extracellular domain determines the agonist pharmacological profile and that this domain does not modify the G protein-coupling profile determined by the seven-transmembrane-domain region of mGlu receptors." @default.
• W2289623110 created "2016-06-24" @default.
• W2289623110 creator A5001554997 @default.
• W2289623110 creator A5016925630 @default.
• W2289623110 creator A5035290703 @default.
• W2289623110 creator A5045863654 @default.
• W2289623110 creator A5069793121 @default.
• W2289623110 creator A5087569154 @default.
• W2289623110 date "1998-04-01" @default.
• W2289623110 modified "2023-10-16" @default.
• W2289623110 title "The G Protein-Coupling Profile of Metabotropic Glutamate Receptors, as Determined with Exogenous G Proteins, Is Independent of Their Ligand Recognition Domain" @default.
• W2289623110 cites W1482828226 @default.
• W2289623110 cites W1506425398 @default.
• W2289623110 cites W1511344849 @default.
• W2289623110 cites W1880336884 @default.
• W2289623110 cites W1893612865 @default.
• W2289623110 cites W1916235480 @default.
• W2289623110 cites W1932718225 @default.
• W2289623110 cites W1950417202 @default.
• W2289623110 cites W1969762570 @default.
• W2289623110 cites W1972183007 @default.
• W2289623110 cites W1975316279 @default.
• W2289623110 cites W1979035442 @default.
• W2289623110 cites W1979067492 @default.
• W2289623110 cites W1980058356 @default.
• W2289623110 cites W1986276041 @default.
• W2289623110 cites W1988182516 @default.
• W2289623110 cites W1996143170 @default.
• W2289623110 cites W2001402428 @default.
• W2289623110 cites W2003492314 @default.
• W2289623110 cites W2005637545 @default.
• W2289623110 cites W2005913521 @default.
• W2289623110 cites W2008052643 @default.
• W2289623110 cites W2009441758 @default.
• W2289623110 cites W2015176049 @default.
• W2289623110 cites W2020791858 @default.
• W2289623110 cites W2023038974 @default.
• W2289623110 cites W2106042714 @default.
• W2289623110 cites W2167767264 @default.
• W2289623110 cites W2346553109 @default.
• W2289623110 cites W2951764089 @default.
• W2289623110 cites W4301951454 @default.
• W2289623110 cites W4321428222 @default.
• W2289623110 doi "https://doi.org/10.1124/mol.53.4.778" @default.
• W2289623110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9547371" @default.
• W2289623110 hasPublicationYear "1998" @default.
• W2289623110 type Work @default.
• W2289623110 sameAs 2289623110 @default.
• W2289623110 citedByCount "74" @default.
• W2289623110 countsByYear W22896231102012 @default.
• W2289623110 countsByYear W22896231102017 @default.
• W2289623110 countsByYear W22896231102019 @default.
• W2289623110 countsByYear W22896231102023 @default.
• W2289623110 crossrefType "journal-article" @default.
• W2289623110 hasAuthorship W2289623110A5001554997 @default.
• W2289623110 hasAuthorship W2289623110A5016925630 @default.
• W2289623110 hasAuthorship W2289623110A5035290703 @default.
• W2289623110 hasAuthorship W2289623110A5045863654 @default.
• W2289623110 hasAuthorship W2289623110A5069793121 @default.
• W2289623110 hasAuthorship W2289623110A5087569154 @default.
• W2289623110 hasConcept C135285700 @default.
• W2289623110 hasConcept C170493617 @default.
• W2289623110 hasConcept C203270574 @default.
• W2289623110 hasConcept C207951395 @default.
• W2289623110 hasConcept C26702167 @default.
• W2289623110 hasConcept C2778597717 @default.
• W2289623110 hasConcept C2778938600 @default.
• W2289623110 hasConcept C42221972 @default.
• W2289623110 hasConcept C49051014 @default.
• W2289623110 hasConcept C55493867 @default.
• W2289623110 hasConcept C80631254 @default.
• W2289623110 hasConcept C86803240 @default.
• W2289623110 hasConceptScore W2289623110C135285700 @default.
• W2289623110 hasConceptScore W2289623110C170493617 @default.
• W2289623110 hasConceptScore W2289623110C203270574 @default.
• W2289623110 hasConceptScore W2289623110C207951395 @default.
• W2289623110 hasConceptScore W2289623110C26702167 @default.
• W2289623110 hasConceptScore W2289623110C2778597717 @default.
• W2289623110 hasConceptScore W2289623110C2778938600 @default.
• W2289623110 hasConceptScore W2289623110C42221972 @default.
• W2289623110 hasConceptScore W2289623110C49051014 @default.
• W2289623110 hasConceptScore W2289623110C55493867 @default.
• W2289623110 hasConceptScore W2289623110C80631254 @default.
• W2289623110 hasConceptScore W2289623110C86803240 @default.
• W2289623110 hasIssue "4" @default.
• W2289623110 hasLocation W22896231101 @default.
• W2289623110 hasLocation W22896231102 @default.
• W2289623110 hasOpenAccess W2289623110 @default.
• W2289623110 hasPrimaryLocation W22896231101 @default.
• W2289623110 hasRelatedWork W1998362587 @default.
• W2289623110 hasRelatedWork W2046996969 @default.
• W2289623110 hasRelatedWork W2059975564 @default.
• W2289623110 hasRelatedWork W2103863804 @default.
• W2289623110 hasRelatedWork W2302250415 @default.
• W2289623110 hasRelatedWork W2575611067 @default.
• W2289623110 hasRelatedWork W2746657404 @default.
• W2289623110 hasRelatedWork W2910792274 @default.
• W2289623110 hasRelatedWork W3204745974 @default.

• next