FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2289628470> ?p ?o ?g. }

• W2289628470 endingPage "e1002394" @default.
• W2289628470 startingPage "e1002394" @default.
• W2289628470 abstract "Horizontal DNA transfer (HDT) is a pervasive mechanism of diversification in many microbial species, but its primary evolutionary role remains controversial. Much recent research has emphasised the adaptive benefit of acquiring novel DNA, but here we argue instead that intragenomic conflict provides a coherent framework for understanding the evolutionary origins of HDT. To test this hypothesis, we developed a mathematical model of a clonally descended bacterial population undergoing HDT through transmission of mobile genetic elements (MGEs) and genetic transformation. Including the known bias of transformation toward the acquisition of shorter alleles into the model suggested it could be an effective means of counteracting the spread of MGEs. Both constitutive and transient competence for transformation were found to provide an effective defence against parasitic MGEs; transient competence could also be effective at permitting the selective spread of MGEs conferring a benefit on their host bacterium. The coordination of transient competence with cell–cell killing, observed in multiple species, was found to result in synergistic blocking of MGE transmission through releasing genomic DNA for homologous recombination while simultaneously reducing horizontal MGE spread by lowering the local cell density. To evaluate the feasibility of the functions suggested by the modelling analysis, we analysed genomic data from longitudinal sampling of individuals carrying Streptococcus pneumoniae. This revealed the frequent within-host coexistence of clonally descended cells that differed in their MGE infection status, a necessary condition for the proposed mechanism to operate. Additionally, we found multiple examples of MGEs inhibiting transformation through integrative disruption of genes encoding the competence machinery across many species, providing evidence of an ongoing “arms race.” Reduced rates of transformation have also been observed in cells infected by MGEs that reduce the concentration of extracellular DNA through secretion of DNases. Simulations predicted that either mechanism of limiting transformation would benefit individual MGEs, but also that this tactic’s effectiveness was limited by competition with other MGEs coinfecting the same cell. A further observed behaviour we hypothesised to reduce elimination by transformation was MGE activation when cells become competent. Our model predicted that this response was effective at counteracting transformation independently of competing MGEs. Therefore, this framework is able to explain both common properties of MGEs, and the seemingly paradoxical bacterial behaviours of transformation and cell–cell killing within clonally related populations, as the consequences of intragenomic conflict between self-replicating chromosomes and parasitic MGEs. The antagonistic nature of the different mechanisms of HDT over short timescales means their contribution to bacterial evolution is likely to be substantially greater than previously appreciated." @default.
• W2289628470 created "2016-06-24" @default.
• W2289628470 creator A5009704937 @default.
• W2289628470 creator A5027792801 @default.
• W2289628470 creator A5029973916 @default.
• W2289628470 creator A5047670057 @default.
• W2289628470 creator A5062645497 @default.
• W2289628470 creator A5077742706 @default.
• W2289628470 date "2016-03-02" @default.
• W2289628470 modified "2023-10-16" @default.
• W2289628470 title "Horizontal DNA Transfer Mechanisms of Bacteria as Weapons of Intragenomic Conflict" @default.
• W2289628470 cites W1502196371 @default.
• W2289628470 cites W1513506754 @default.
• W2289628470 cites W1520257721 @default.
• W2289628470 cites W1539727497 @default.
• W2289628470 cites W1545005352 @default.
• W2289628470 cites W1557004712 @default.
• W2289628470 cites W1565127133 @default.
• W2289628470 cites W1584241287 @default.
• W2289628470 cites W1589860931 @default.
• W2289628470 cites W1590887889 @default.
• W2289628470 cites W1702157588 @default.
• W2289628470 cites W1826289122 @default.
• W2289628470 cites W1838187139 @default.
• W2289628470 cites W1889291941 @default.
• W2289628470 cites W1893024407 @default.
• W2289628470 cites W1922230754 @default.
• W2289628470 cites W1967668980 @default.
• W2289628470 cites W1967902778 @default.
• W2289628470 cites W1969978016 @default.
• W2289628470 cites W1971115321 @default.
• W2289628470 cites W1971117019 @default.
• W2289628470 cites W1972145956 @default.
• W2289628470 cites W1975473907 @default.
• W2289628470 cites W1977405831 @default.
• W2289628470 cites W1978329448 @default.
• W2289628470 cites W1979477952 @default.
• W2289628470 cites W1980137739 @default.
• W2289628470 cites W1980376537 @default.
• W2289628470 cites W1980568064 @default.
• W2289628470 cites W1980595924 @default.
• W2289628470 cites W1985891064 @default.
• W2289628470 cites W1990604707 @default.
• W2289628470 cites W1995136541 @default.
• W2289628470 cites W1996018872 @default.
• W2289628470 cites W2001697756 @default.
• W2289628470 cites W2006716355 @default.
• W2289628470 cites W2008088946 @default.
• W2289628470 cites W2009320470 @default.
• W2289628470 cites W2009625348 @default.
• W2289628470 cites W2012266043 @default.
• W2289628470 cites W2012457803 @default.
• W2289628470 cites W2012513753 @default.
• W2289628470 cites W2013041427 @default.
• W2289628470 cites W2014496483 @default.
• W2289628470 cites W2016935145 @default.
• W2289628470 cites W2018366249 @default.
• W2289628470 cites W2018526864 @default.
• W2289628470 cites W2018802430 @default.
• W2289628470 cites W2019197162 @default.
• W2289628470 cites W2021780844 @default.
• W2289628470 cites W2024781134 @default.
• W2289628470 cites W2025070182 @default.
• W2289628470 cites W2025122624 @default.
• W2289628470 cites W2027831845 @default.
• W2289628470 cites W2033205630 @default.
• W2289628470 cites W2034302623 @default.
• W2289628470 cites W2036775991 @default.
• W2289628470 cites W2037409969 @default.
• W2289628470 cites W2037827003 @default.
• W2289628470 cites W2038838144 @default.
• W2289628470 cites W2039227019 @default.
• W2289628470 cites W2041949408 @default.
• W2289628470 cites W2041988148 @default.
• W2289628470 cites W2042050496 @default.
• W2289628470 cites W2043083543 @default.
• W2289628470 cites W2043932025 @default.
• W2289628470 cites W2046654639 @default.
• W2289628470 cites W2047654729 @default.
• W2289628470 cites W2052004561 @default.
• W2289628470 cites W2052419566 @default.
• W2289628470 cites W2055079545 @default.
• W2289628470 cites W2059652284 @default.
• W2289628470 cites W2061092522 @default.
• W2289628470 cites W2061969008 @default.
• W2289628470 cites W2065857450 @default.
• W2289628470 cites W2074659247 @default.
• W2289628470 cites W2074726414 @default.
• W2289628470 cites W2077184748 @default.
• W2289628470 cites W2078420554 @default.
• W2289628470 cites W2080163848 @default.
• W2289628470 cites W2096415729 @default.
• W2289628470 cites W2100977464 @default.
• W2289628470 cites W2102257617 @default.
• W2289628470 cites W2103441770 @default.
• W2289628470 cites W2106484287 @default.
• W2289628470 cites W2109006121 @default.
• W2289628470 cites W2110257644 @default.

• next