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- W2289640572 abstract "The authors note that these new definitions are dynamic and subject to improvement by an iterative process. Further, these guidelines are tailored strictly for surveillance and are not meant to guide clinical decision making. Future work will be necessary to determine the associations between this new surveillance definition and important clinical outcomes. Ultimately, rather than being simply descriptive, implementation of monitoring guidelines should also drive improved patient outcomes—both through prevention and early detection. The VAE algorithm in its current implementation will facilitate multicentered studies to evaluate preventative strategies to reduce the prevalence of VAP. Additionally, early detection of VACs will require methods to quickly differentiate true VAP from the milieu of VAP-mimics. Use of alternative markers of pulmonary infection—including serum procalcitonin and soluble triggering receptor expressed on myeloid cells-1 from bronchoalveolar lavage fluid—have been shown to be of limited utility in the early diagnosis of VAP (11, 12). However, it is possible that molecular diagnostic techniques, such as quantitative polymerase chain reaction, could assist in early detection of nosocomial infections when the antimicrobial burden is low (13). Other promising technologies include volatile metabolic compound detection and analysis using gas chromatography for specific bacterial markers (14). It is possible that these future clinical diagnostic advances could ultimately lead to more timely, responsible, and effective antibiotic use. We welcome the new approach to VAE surveillance described in this issue as a necessary step in ongoing advancement in the field. REFERENCES 1. Klompas M: Does this patient have ventilator-associated pneumonia?" @default.
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- W2289640572 date "2013-01-01" @default.
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- W2289640572 title "Routine Intra-Aortic Balloon Pump Support in High-Risk Cardiac Surgery Patients: Is It Time to Throw Away the Pump?*" @default.
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