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• W2289657943 endingPage "103" @default.
• W2289657943 startingPage "92" @default.
• W2289657943 abstract "Due to the complex physiology of the testes, in vitro models have been largely unsuccessful at modeling testicular toxicity in vivo. We conducted a pilot study to evaluate the utility of the Durand ex vivo rat seminiferous tubule culture model [1], [2], [3] that supports spermatogenesis through meiosis II, including the formation of round spermatids. We used this system to evaluate the toxicity of four known testicular toxicants: 1,3-dinitrobenzene (DNB), 2-methoxyacetic acid (MAA), bisphenol A (BPA), and lindane over 21 days of culture. This organotypic culture system demonstrated the ability to successfully model in vivo testicular toxicity (Sertoli cell toxicity and disruption of meiosis) for all four compounds. These findings support the application of this system to study molecules and evaluate mechanisms of testicular toxicity." @default.
• W2289657943 created "2016-06-24" @default.
• W2289657943 creator A5006068006 @default.
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• W2289657943 creator A5037797694 @default.
• W2289657943 date "2016-04-01" @default.
• W2289657943 modified "2023-09-25" @default.
• W2289657943 title "Use of a rat ex-vivo testis culture method to assess toxicity of select known male reproductive toxicants" @default.
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• W2289657943 doi "https://doi.org/10.1016/j.reprotox.2016.01.003" @default.
• W2289657943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26802500" @default.
• W2289657943 hasPublicationYear "2016" @default.
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