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• W2289667525 abstract "// Maria J. De Herdt 1, * , Stefan M. Willems 2, * , Berdine van der Steen 1, ** , Rob Noorlag 2, 3, ** , Esther I. Verhoef 4 , Geert J.L.H. van Leenders 4 , Robert J.J. van Es 3 , Senada Koljenović 4 , Robert J. Baatenburg de Jong 1, *** , Leendert H.J. Looijenga 4, *** 1 Department of Othorhinolaryngology and Head and Neck Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands 2 Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands 3 Department of Oral and Maxillofacial Surgery, University Medical Center Utrecht, Utrecht, The Netherlands 4 Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands *, **, *** The authors contributed equally to this work as co-first, second and final authors respectively Correspondence to: Leendert H.J. Looijenga, e-mail: l.looijenga@erasmusmc.nl Keywords: oral and oropharyngeal squamous cell carcinoma, C-terminal MET, immunohistochemistry, antibody validation, prognosis Received: August 07, 2015     Accepted: January 01, 2016     Published: February 20, 2016 ABSTRACT Although the receptor tyrosine kinase (RTK) MET is widely expressed in head and neck squamous cell carcinoma (HNSCC), its prognostic value remains unclear. This might be due to the use of a variety of antibodies and scoring systems. Here, the reliability of five commercial C-terminal MET antibodies (D1C2, CVD13, SP44, C-12 and C-28) was evaluated before examining the prognostic value of MET immunoreactivity in HNSCC. Using cancer cell lines, it was shown that D1C2 and CVD13 specifically detect MET under reducing, native and formalin-fixed paraffin-embedded (FFPE) conditions. Immunohistochemical staining of routinely FFPE oral SCC with D1C2 and CVD13 demonstrated that D1C2 is most sensitive in the detection of membranous MET. Examination of membranous D1C2 immunoreactivity with 179 FFPE oral and oropharyngeal SCC – represented in a tissue microarray – illustrated that staining is either uniform (negative or positive) across tumors or differs between a tumor’s center and periphery. Ultimately, statistical analysis revealed that D1C2 uniform staining is significantly associated with poor 5-year overall and disease free survival of patients lacking vasoinvasive growth (HR = 3.019, p < 0.001; HR = 2.559, p < 0.001). These findings might contribute to reliable stratification of patients eligible for treatment with biologicals directed against MET." @default.
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• W2289667525 date "2016-02-20" @default.
• W2289667525 modified "2023-09-27" @default.
• W2289667525 title "Absent and abundant MET immunoreactivity is associated with poor prognosis of patients with oral and oropharyngeal squamous cell carcinoma" @default.
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• W2289667525 doi "https://doi.org/10.18632/oncotarget.7534" @default.
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