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- W2289712910 abstract "Complete initial resection can give cancer patients the best opportunity for long-term survival. There is unmet need insurgical oncology for optical imaging that enables simple and precise visualization of tumors and consistent contrast withsurrounding normal tissues. Near-infrared (NIR) contrast agents and camera systems that can detect them represent anarea of active research and development. The investigational Tumor Paint agent BLZ-100 is a conjugate of a chlorotoxinpeptide and the NIR dye indocyanine green (ICG) that has been shown to specifically bind to a broad range of solidtumors. Clinical efficacy studies with BLZ-100 are in progress, a necessary step in bringing the product into clinicalpractice. To ensure a product that will be useful for and accepted by surgeons, the early clinical development of BLZ-100 incorporates multiple tumor types and imaging devices so that surgeon feedback covers the range of anticipatedclinical uses. Key contrast agent characteristics include safety, specificity, flexibility in timing between dose and surgery,and breadth of tumor types recognized. Imaging devices should use wavelengths that are optimal for the contrast agent,be sensitive enough that contrast agent dosing can be adjusted for optimal contrast, include real-time video display offluorescence and white light image, and be simple for surgeons to use with minimal disruption of surgical flow. Rapidentry into clinical studies provides the best opportunity for early surgeon feedback, enabling development of agents anddevices that will gain broad acceptance and provide information that helps surgeons achieve more complete and preciseresections." @default.
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- W2289712910 date "2016-03-04" @default.
- W2289712910 modified "2023-09-23" @default.
- W2289712910 title "Clinical development of BLZ-100 for real-time optical imaging of tumors during resection" @default.
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- W2289712910 doi "https://doi.org/10.1117/12.2224856" @default.
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