FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2289718481> ?p ?o ?g. }

• W2289718481 endingPage "2258" @default.
• W2289718481 startingPage "2245" @default.
• W2289718481 abstract "Cancer patients die primarily due to disease recurrence after transient treatment responses. The emergence of therapy-resistant escape variants is fuelled by intra-tumour heterogeneity, underpinned by interference and Darwinian evolution among continuously developing sub-clones in the mutating tumour. Novel cancer cell variants build upon the pre-existing genetic landscape and tumour heterogeneity is often ascribed largely to genetic variability. While mutations are required for cancer development and studies of genetic evolution of tumours have improved our understanding of cancer biology, genetics only represents one dimension of the fitness of each cancer cell. Beyond the mutations, several non-genetic factors also add significant variability, resulting in a complex and highly dynamic tumour cell population that can drive disease under almost any condition. This viewpoint article summarizes the genetic basis of intra-tumour heterogeneity, before dissecting four major interdependent non-genetic factors we think critically contribute to the overall variability of tumour cells in all types of cancer: epigenetic regulation, cellular differentiation hierarchies, gene expression stochasticity and tumour microenvironment. We finally present the relevant technological approaches to address the combined contribution of both genetic and non-genetic factors to intra-tumour heterogeneity, focusing on genomic profiling, cellular lineage tracing and single-cell RNA sequencing technologies. This strategy will ultimately allow dissection of the full range and depth of intra-tumour heterogeneity. We thus believe that understanding how cancer genetics synergize with the emerging non-genetic factors will be key for development of therapies able to tackle tumour escape and thereby improve cancer patient survival." @default.
• W2289718481 created "2016-06-24" @default.
• W2289718481 creator A5030043762 @default.
• W2289718481 creator A5030791136 @default.
• W2289718481 creator A5041150382 @default.
• W2289718481 date "2016-04-01" @default.
• W2289718481 modified "2023-10-18" @default.
• W2289718481 title "Intra-tumour heterogeneity - going beyond genetics" @default.
• W2289718481 cites W1503622815 @default.
• W2289718481 cites W1533281077 @default.
• W2289718481 cites W1566672792 @default.
• W2289718481 cites W1701091641 @default.
• W2289718481 cites W1903281529 @default.
• W2289718481 cites W1963670229 @default.
• W2289718481 cites W1967217180 @default.
• W2289718481 cites W1967304777 @default.
• W2289718481 cites W1967358345 @default.
• W2289718481 cites W1967563925 @default.
• W2289718481 cites W1968657935 @default.
• W2289718481 cites W1968895970 @default.
• W2289718481 cites W1972587504 @default.
• W2289718481 cites W1973568247 @default.
• W2289718481 cites W1974798136 @default.
• W2289718481 cites W1984429906 @default.
• W2289718481 cites W1987191607 @default.
• W2289718481 cites W1989004419 @default.
• W2289718481 cites W1995824006 @default.
• W2289718481 cites W2004488361 @default.
• W2289718481 cites W2004834404 @default.
• W2289718481 cites W2004878973 @default.
• W2289718481 cites W2007196889 @default.
• W2289718481 cites W2008271309 @default.
• W2289718481 cites W2009392791 @default.
• W2289718481 cites W2009886857 @default.
• W2289718481 cites W2011563103 @default.
• W2289718481 cites W2018288777 @default.
• W2289718481 cites W2023560061 @default.
• W2289718481 cites W2025998934 @default.
• W2289718481 cites W2030017878 @default.
• W2289718481 cites W2032518018 @default.
• W2289718481 cites W2035151737 @default.
• W2289718481 cites W2041380745 @default.
• W2289718481 cites W2041686632 @default.
• W2289718481 cites W2043772256 @default.
• W2289718481 cites W2044433401 @default.
• W2289718481 cites W2045825103 @default.
• W2289718481 cites W2048060724 @default.
• W2289718481 cites W2064442490 @default.
• W2289718481 cites W2066254965 @default.
• W2289718481 cites W2070577306 @default.
• W2289718481 cites W2072479313 @default.
• W2289718481 cites W2081270564 @default.
• W2289718481 cites W2086239091 @default.
• W2289718481 cites W2088580309 @default.
• W2289718481 cites W2093144236 @default.
• W2289718481 cites W2097536603 @default.
• W2289718481 cites W2098970540 @default.
• W2289718481 cites W2099851046 @default.
• W2289718481 cites W2100543432 @default.
• W2289718481 cites W2104895468 @default.
• W2289718481 cites W2106391833 @default.
• W2289718481 cites W2110232607 @default.
• W2289718481 cites W2110612987 @default.
• W2289718481 cites W2111471857 @default.
• W2289718481 cites W2112239573 @default.
• W2289718481 cites W2116922866 @default.
• W2289718481 cites W2117034500 @default.
• W2289718481 cites W2117737648 @default.
• W2289718481 cites W2126903025 @default.
• W2289718481 cites W2129297473 @default.
• W2289718481 cites W2129375080 @default.
• W2289718481 cites W2134811927 @default.
• W2289718481 cites W2135523574 @default.
• W2289718481 cites W2136272158 @default.
• W2289718481 cites W2143197030 @default.
• W2289718481 cites W2144845076 @default.
• W2289718481 cites W2150575159 @default.
• W2289718481 cites W2151199601 @default.
• W2289718481 cites W2152177323 @default.
• W2289718481 cites W2152716163 @default.
• W2289718481 cites W2153010521 @default.
• W2289718481 cites W2156674847 @default.
• W2289718481 cites W2160450758 @default.
• W2289718481 cites W2160807638 @default.
• W2289718481 cites W2163235555 @default.
• W2289718481 cites W2164327622 @default.
• W2289718481 cites W2168631000 @default.
• W2289718481 cites W2169895148 @default.
• W2289718481 cites W2171501288 @default.
• W2289718481 cites W2182664595 @default.
• W2289718481 cites W2274471144 @default.
• W2289718481 doi "https://doi.org/10.1111/febs.13705" @default.
• W2289718481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26945550" @default.
• W2289718481 hasPublicationYear "2016" @default.
• W2289718481 type Work @default.
• W2289718481 sameAs 2289718481 @default.
• W2289718481 citedByCount "70" @default.
• W2289718481 countsByYear W22897184812016 @default.

• next