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• W2289742030 abstract "Summary Crimean-Congo hemorrhagic fever is one of the most widely distributed viral hemorrhagic fevers with a high case fatality rate. This virus is a member of the genus Nairovirus in the family Bunyaviridae. The disease was first discovered in the Crimean region of Russia in the 1940s and is now reported in many regions of the world. The virus is transmitted to humans by the bite of Ixodid tick mostly of the Hyalomma genus or by contact with blood or tissues from human patients or infected livestock .Virus spreads from the initial infection site to regional lymph nodes, liver and spleen. At these sites, the virus infects tissue macrophages including Kupffer cells and dendritic cells. Horizontal transmission from a mother to her child has also been reported. Fever, headache, myalgia, arthralgia, abdominal pain and vomiting, sore throat, conjunctivitis, jaundice, photophobia and various sensory and mood alterations may develop after infection. Diagnosis is done with microscopic examination, immunoassay technique and nucleic acid detection test. Ribavirin orally and parenterally, specific immunoglobulin CCHFVenin and vaccine for CCHF derived from inactivated mouse brain is used for treatment but the efficacy of this vaccine is not well quantified . Avoiding virus exposure, tick control, vertebrate control and barrier nursing of patients would be essential for prevention of disease." @default.
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• W2289742030 date "2009-01-01" @default.
• W2289742030 modified "2023-09-27" @default.
• W2289742030 title "CRIMEAN-CONGO HEMORRHAGIC FEVER: A REVIEW" @default.
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