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• W2289742522 endingPage "552" @default.
• W2289742522 startingPage "519" @default.
• W2289742522 abstract "We summarize our experience with 238 cases of Langerhans cell granulomatosis (LCG), 198 of whom were followed for a median period of 10.5 years. Our patients did well unless overtreated, and no deaths were attributed to the disorder itself. The disease may appear in unifocal or multifocal form, and treatment is based on this fact. Virtually all patients recovered completely except for occasional residual orthopedic problems or residual diabetes insipidus. Several of the patients underwent subsequent pregnancies without difficulty. The granulomas primarily occur in bone, but lung, skin, and lymph nodal involvement is not uncommon. Involvement of thyroid, thymus, and other sites is rare. The hallmark of the disease is the accumulation of Langerhans cells (LCs). We review the pathology of LCG by histology, electron microscopy, and immunolabeling. LCs originally were identified in squamous epithelium, but these cells are part of the widespread system of dendritic cells. The latter cells, which arise from CD34+ progenitors, are specialized and efficient antigen-presenting cells for T-cell-mediated immunity. In LCG, however, the major associated cells are not T cells, but mature eosinophils: hence the original name eosinophilic granuloma. Confusion about terminology has been based upon the scanty and rather crude pathology reports in the original literature. The term histiocytosis X was meant to cover a spectrum of three diseases—eosinophilic granuloma, Hand-Schüller-Christian disease (HSC), and Letterer-Siwe disease (LS)—but HSC and LS have no basis in pathology and hence the terms are meaningless. The term HSC has become a synonym for multifocal eosinophilic granuloma (LCG). The term LS has been used in reporting a number of benign, malignant, or unknown conditions. We prefer the term LCG to avoid confusion with the term histiocytosis X because there is evidence that the LC is not a member of the mononuclear phagocyte system and hence not a tissue macrophage, and because the use of the term “histiocyte” has become a convenience in much of the literature when reporting incompletely understood diseases." @default.
• W2289742522 created "2016-06-24" @default.
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• W2289742522 date "1996-05-01" @default.
• W2289742522 modified "2023-10-17" @default.
• W2289742522 title "Langerhans Cell (Eosinophilic) Granulomatosis" @default.
• W2289742522 cites W1552439729 @default.
• W2289742522 cites W1570223032 @default.
• W2289742522 cites W1956446122 @default.
• W2289742522 cites W1966170131 @default.
• W2289742522 cites W1966842691 @default.
• W2289742522 cites W1972860394 @default.
• W2289742522 cites W1974120362 @default.
• W2289742522 cites W1976578416 @default.
• W2289742522 cites W1980255149 @default.
• W2289742522 cites W1981000497 @default.
• W2289742522 cites W1985306024 @default.
• W2289742522 cites W1992241657 @default.
• W2289742522 cites W1992672455 @default.
• W2289742522 cites W1994333845 @default.
• W2289742522 cites W1998202978 @default.
• W2289742522 cites W1998785432 @default.
• W2289742522 cites W2001838727 @default.
• W2289742522 cites W2004789549 @default.
• W2289742522 cites W2005657826 @default.
• W2289742522 cites W2011092556 @default.
• W2289742522 cites W2011355391 @default.
• W2289742522 cites W2017388697 @default.
• W2289742522 cites W2018391601 @default.
• W2289742522 cites W2019546595 @default.
• W2289742522 cites W2021873237 @default.
• W2289742522 cites W2027357576 @default.
• W2289742522 cites W2028899386 @default.
• W2289742522 cites W2032578068 @default.
• W2289742522 cites W2032828859 @default.
• W2289742522 cites W2033503550 @default.
• W2289742522 cites W2036010141 @default.
• W2289742522 cites W2036018466 @default.
• W2289742522 cites W2036508796 @default.
• W2289742522 cites W2036968156 @default.
• W2289742522 cites W2038506743 @default.
• W2289742522 cites W2039843355 @default.
• W2289742522 cites W2043710695 @default.
• W2289742522 cites W2044784702 @default.
• W2289742522 cites W2045149615 @default.
• W2289742522 cites W2046626009 @default.
• W2289742522 cites W2047147856 @default.
• W2289742522 cites W2047269376 @default.
• W2289742522 cites W2050335718 @default.
• W2289742522 cites W2053877599 @default.
• W2289742522 cites W2054637750 @default.
• W2289742522 cites W2057878167 @default.
• W2289742522 cites W2058372496 @default.
• W2289742522 cites W2058774596 @default.
• W2289742522 cites W2060244327 @default.
• W2289742522 cites W2063229820 @default.
• W2289742522 cites W2063907935 @default.
• W2289742522 cites W2065985589 @default.
• W2289742522 cites W2067460671 @default.
• W2289742522 cites W2075243665 @default.
• W2289742522 cites W2083541450 @default.
• W2289742522 cites W2084390981 @default.
• W2289742522 cites W2084771620 @default.
• W2289742522 cites W2087826373 @default.
• W2289742522 cites W2088005472 @default.
• W2289742522 cites W2088417334 @default.
• W2289742522 cites W2090735007 @default.
• W2289742522 cites W2097674485 @default.
• W2289742522 cites W2111160128 @default.
• W2289742522 cites W2131849577 @default.
• W2289742522 cites W2136748948 @default.
• W2289742522 cites W2146795754 @default.
• W2289742522 cites W2155372120 @default.
• W2289742522 cites W2164364335 @default.
• W2289742522 cites W2165054204 @default.
• W2289742522 cites W2165163034 @default.
• W2289742522 cites W2166676682 @default.
• W2289742522 cites W2177327503 @default.
• W2289742522 cites W2301366231 @default.
• W2289742522 cites W2318299971 @default.
• W2289742522 cites W2324313464 @default.
• W2289742522 cites W2325716909 @default.
• W2289742522 cites W2329394186 @default.
• W2289742522 cites W2332277465 @default.
• W2289742522 cites W2398841566 @default.
• W2289742522 cites W2399071388 @default.
• W2289742522 cites W2407117604 @default.

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