Matches in SemOpenAlex for { <https://semopenalex.org/work/W2289749480> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2289749480 abstract "Aim. To research on the influence of polymorphism G681A gene CYP2C19 on efficacy of clopidogrel for planned endovascular treatment in stable CHD with second type diabetes. Material and methods. Totally 242 patients included, with chronic CHD, underwent planned angioplastics and stenting of coronary arteries. Of those 79 had 2nd type DM. All patients received double antiplatelet therapy, including acetylsalicylic acid and clopidogrel. For efficacy evaluation, we performed the test of induced platelet aggregation with ADP in 2,5 and 5,0 mcM concentrations after total dose of clopidogrel 300 mg. Genotyping was done with allele-specific polymerase chain reaction with commercial panel “SNP-express” (SPC “LITECH”, Moscow). Results. In our selection, the carriers of allele A differed from homozygous GG with an increased grade of platelet aggregation in ADP stimulation, concentrations 2,5 mcM and 5,0 mcM. While selecting subgroups according to diabetes existence, the mention association was found in non-diabetic group, but not in comorbidity group (CHD and DM). In GG genotype, patients having 2 type DM showed the grade of induced platelet aggregation higher than in carriers of the same genotype without DM. At the same time, allele A carriers without DM did not differ from comorbidity selection in sense of ADP induced response of platelets. Conclusion. So, A allele carriage of G681A polymorphism of gene CYP2C19 is a risk factor for lower clopidogrel efficacy. Diabetes of second type also negatively influences the sensitivity to clopidogrel, but only in GG homozygous." @default.
- W2289749480 created "2016-06-24" @default.
- W2289749480 creator A5002825551 @default.
- W2289749480 creator A5025270990 @default.
- W2289749480 creator A5046553984 @default.
- W2289749480 creator A5076458593 @default.
- W2289749480 date "2015-11-28" @default.
- W2289749480 modified "2023-10-16" @default.
- W2289749480 title "GENE CYP2C19 POLYMORPHISM G681A INFLUENCE ON THE EFFICACY OF CLOPIDOGREL IN ENDOVASCULAR TREATMENT OF ISCHEMIC HEART DISEASE COMORBID WITH TYPE 2 DIABETES" @default.
- W2289749480 doi "https://doi.org/10.15829/1560-4071-2015-10-81-85" @default.
- W2289749480 hasPublicationYear "2015" @default.
- W2289749480 type Work @default.
- W2289749480 sameAs 2289749480 @default.
- W2289749480 citedByCount "0" @default.
- W2289749480 crossrefType "journal-article" @default.
- W2289749480 hasAuthorship W2289749480A5002825551 @default.
- W2289749480 hasAuthorship W2289749480A5025270990 @default.
- W2289749480 hasAuthorship W2289749480A5046553984 @default.
- W2289749480 hasAuthorship W2289749480A5076458593 @default.
- W2289749480 hasBestOaLocation W22897494801 @default.
- W2289749480 hasConcept C104317684 @default.
- W2289749480 hasConcept C126322002 @default.
- W2289749480 hasConcept C134018914 @default.
- W2289749480 hasConcept C135763542 @default.
- W2289749480 hasConcept C140840227 @default.
- W2289749480 hasConcept C149737253 @default.
- W2289749480 hasConcept C164705383 @default.
- W2289749480 hasConcept C2777180221 @default.
- W2289749480 hasConcept C2777628954 @default.
- W2289749480 hasConcept C2777849778 @default.
- W2289749480 hasConcept C2779134260 @default.
- W2289749480 hasConcept C526171541 @default.
- W2289749480 hasConcept C54355233 @default.
- W2289749480 hasConcept C555293320 @default.
- W2289749480 hasConcept C62231903 @default.
- W2289749480 hasConcept C71924100 @default.
- W2289749480 hasConcept C86803240 @default.
- W2289749480 hasConceptScore W2289749480C104317684 @default.
- W2289749480 hasConceptScore W2289749480C126322002 @default.
- W2289749480 hasConceptScore W2289749480C134018914 @default.
- W2289749480 hasConceptScore W2289749480C135763542 @default.
- W2289749480 hasConceptScore W2289749480C140840227 @default.
- W2289749480 hasConceptScore W2289749480C149737253 @default.
- W2289749480 hasConceptScore W2289749480C164705383 @default.
- W2289749480 hasConceptScore W2289749480C2777180221 @default.
- W2289749480 hasConceptScore W2289749480C2777628954 @default.
- W2289749480 hasConceptScore W2289749480C2777849778 @default.
- W2289749480 hasConceptScore W2289749480C2779134260 @default.
- W2289749480 hasConceptScore W2289749480C526171541 @default.
- W2289749480 hasConceptScore W2289749480C54355233 @default.
- W2289749480 hasConceptScore W2289749480C555293320 @default.
- W2289749480 hasConceptScore W2289749480C62231903 @default.
- W2289749480 hasConceptScore W2289749480C71924100 @default.
- W2289749480 hasConceptScore W2289749480C86803240 @default.
- W2289749480 hasLocation W22897494801 @default.
- W2289749480 hasLocation W22897494802 @default.
- W2289749480 hasOpenAccess W2289749480 @default.
- W2289749480 hasPrimaryLocation W22897494801 @default.
- W2289749480 hasRelatedWork W1981534865 @default.
- W2289749480 hasRelatedWork W2081405889 @default.
- W2289749480 hasRelatedWork W2315758071 @default.
- W2289749480 hasRelatedWork W2323296171 @default.
- W2289749480 hasRelatedWork W2336778042 @default.
- W2289749480 hasRelatedWork W2382099534 @default.
- W2289749480 hasRelatedWork W3160607049 @default.
- W2289749480 hasRelatedWork W4234973638 @default.
- W2289749480 hasRelatedWork W65716783 @default.
- W2289749480 hasRelatedWork W2133941332 @default.
- W2289749480 isParatext "false" @default.
- W2289749480 isRetracted "false" @default.
- W2289749480 magId "2289749480" @default.
- W2289749480 workType "article" @default.