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- W2289781313 endingPage "20150071" @default.
- W2289781313 startingPage "20150071" @default.
- W2289781313 abstract "Despite advancements in technology and science over the last century, the mechanisms underlying Wolff's law—bone structure adaptation in response to physical stimuli—remain poorly understood, limiting the ability to effectively treat and prevent skeletal diseases. A challenge to overcome in the study of the underlying mechanisms of this principle is the multiscale nature of mechanoadaptation. While there exist in silico systems that are capable of studying across these scales, experimental studies are typically limited to interpretation at a single dimension or time point. For instance, studies of single-cell responses to defined physical stimuli offer only a limited prediction of the whole bone response, while overlapping pathways or compensatory mechanisms complicate the ability to isolate critical targets in a whole animal model. Thus, there exists a need to develop experimental systems capable of bridging traditional experimental approaches and informing existing multiscale theoretical models. The purpose of this article is to review the process of mechanoadaptation and inherent challenges in studying its underlying mechanisms, discuss the limitations of traditional experimental systems in capturing the many facets of this process and highlight three multiscale experimental systems which bridge traditional approaches and cover relatively understudied time and length scales in bone adaptation." @default.
- W2289781313 created "2016-06-24" @default.
- W2289781313 creator A5030088055 @default.
- W2289781313 creator A5043835575 @default.
- W2289781313 creator A5054959887 @default.
- W2289781313 date "2016-02-06" @default.
- W2289781313 modified "2023-10-16" @default.
- W2289781313 title "Experimental studies of bone mechanoadaptation: bridging <i>in vitro</i> and <i>in vivo</i> studies with multiscale systems" @default.
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