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- W2289805503 endingPage "59" @default.
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- W2289805503 abstract "Genome-wide molecular studies have provided new insights into the organization of nuclear chromatin by revealing the presence of chromatin domains of differing transcriptional activity, frequency of cis-interactions, proximity to scaffolding structures and replication timing. These studies have not only brought our understanding of genome function to a new level, but also offered functional insight for many phenomena observed in microscopic studies. In this review, we discuss the major principles of nuclear organization based on the spatial segregation of euchromatin and heterochromatin, as well as the dynamic genome rearrangements occurring during cell differentiation and development. We hope to unite the existing molecular and microscopic data on genome organization to get a holistic view of the nucleus, and propose a model, in which repeat repertoire together with scaffolding structures blueprint the functional nuclear architecture." @default.
- W2289805503 created "2016-06-24" @default.
- W2289805503 creator A5074447669 @default.
- W2289805503 creator A5081645133 @default.
- W2289805503 creator A5089995480 @default.
- W2289805503 date "2016-06-01" @default.
- W2289805503 modified "2023-10-12" @default.
- W2289805503 title "How to rule the nucleus: divide et impera" @default.
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