FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2289810771> ?p ?o ?g. }

• W2289810771 endingPage "2935" @default.
• W2289810771 startingPage "2926" @default.
• W2289810771 abstract "The promoter of the human major histocompatibility complex class II-associated invariant-chain gene (Ii) contains two NF-kappa B/Rel binding sites located at -109 to -118 (Ii kappa B-1) and -163 to -172 (Ii kappa B-2) from the transcription start site. We report here that the differential function of each of these NF-kappa B/Rel sites in several distinct cell types depends on cell-specific binding of NF-kappa B/Rel transcription factors. Ii kappa B-1 is a positive regulatory element in B-cell lines and in the Ii-expressing T-cell line, H9, but acts as a negative regulatory element in myelomonocytic and glia cell lines. In vivo protein-DNA contacts are detectable at Ii kappa B-1 in cell lines in which this site is functional as either a positive or negative regulator. Electrophoretic mobility supershift assays determine that members of the NF-kappa B/Rel family of transcription factors can bind to this site in vitro and that DNA-binding complexes that contain p50, p52, p65, and cRel correlate with positive regulation whereas the presence of p50 correlates with negative regulation. Ii kappa B-2 is a site of positive regulation in B-cell lines and a site of negative regulation in H9 T cells, myelomonocytic, and glial cell lines. In vivo occupancy of this site is observed only in the H9 T-cell line. Again, in vitro supershift studies indicate that the presence of p50, p52, p65, and cRel correlates with positive function whereas the presence of only p50 and p52 correlates with negative function. This differential binding of specific NF-kappa B/Rel subunits is likely to mediate the disparate functions of these two NF-kappa B/Rel binding sites." @default.
• W2289810771 created "2016-06-24" @default.
• W2289810771 creator A5012884643 @default.
• W2289810771 creator A5014221796 @default.
• W2289810771 creator A5019419731 @default.
• W2289810771 creator A5025142463 @default.
• W2289810771 creator A5034236608 @default.
• W2289810771 creator A5035472398 @default.
• W2289810771 creator A5055704415 @default.
• W2289810771 date "1994-05-01" @default.
• W2289810771 modified "2023-09-26" @default.
• W2289810771 title "Function of NF-kappa B/Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa B/Rel subunits" @default.
• W2289810771 cites W1560739022 @default.
• W2289810771 cites W1599783101 @default.
• W2289810771 cites W1603650405 @default.
• W2289810771 cites W1891003733 @default.
• W2289810771 cites W1933156589 @default.
• W2289810771 cites W1963687107 @default.
• W2289810771 cites W1965848474 @default.
• W2289810771 cites W1969419107 @default.
• W2289810771 cites W1971172755 @default.
• W2289810771 cites W1973173532 @default.
• W2289810771 cites W1976563345 @default.
• W2289810771 cites W1977348907 @default.
• W2289810771 cites W1984441851 @default.
• W2289810771 cites W1986683530 @default.
• W2289810771 cites W1991606993 @default.
• W2289810771 cites W1994008174 @default.
• W2289810771 cites W1994789578 @default.
• W2289810771 cites W1995184275 @default.
• W2289810771 cites W2006115758 @default.
• W2289810771 cites W2006392794 @default.
• W2289810771 cites W2030861677 @default.
• W2289810771 cites W2045359784 @default.
• W2289810771 cites W2046549221 @default.
• W2289810771 cites W2053111401 @default.
• W2289810771 cites W2063500485 @default.
• W2289810771 cites W2068075655 @default.
• W2289810771 cites W2073017063 @default.
• W2289810771 cites W2073993982 @default.
• W2289810771 cites W2088545432 @default.
• W2289810771 cites W2099677521 @default.
• W2289810771 cites W2102966709 @default.
• W2289810771 cites W2105365352 @default.
• W2289810771 cites W2105896882 @default.
• W2289810771 cites W2108227789 @default.
• W2289810771 cites W2112260561 @default.
• W2289810771 cites W2118806683 @default.
• W2289810771 cites W2144515939 @default.
• W2289810771 cites W2146033027 @default.
• W2289810771 cites W227580377 @default.
• W2289810771 cites W2487235062 @default.
• W2289810771 cites W2888511473 @default.
• W2289810771 cites W4293247451 @default.
• W2289810771 doi "https://doi.org/10.1128/mcb.14.5.2926-2935.1994" @default.
• W2289810771 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/358660" @default.
• W2289810771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8164652" @default.
• W2289810771 hasPublicationYear "1994" @default.
• W2289810771 type Work @default.
• W2289810771 sameAs 2289810771 @default.
• W2289810771 citedByCount "16" @default.
• W2289810771 countsByYear W22898107712012 @default.
• W2289810771 countsByYear W22898107712014 @default.
• W2289810771 countsByYear W22898107712016 @default.
• W2289810771 countsByYear W22898107712018 @default.
• W2289810771 crossrefType "journal-article" @default.
• W2289810771 hasAuthorship W2289810771A5012884643 @default.
• W2289810771 hasAuthorship W2289810771A5014221796 @default.
• W2289810771 hasAuthorship W2289810771A5019419731 @default.
• W2289810771 hasAuthorship W2289810771A5025142463 @default.
• W2289810771 hasAuthorship W2289810771A5034236608 @default.
• W2289810771 hasAuthorship W2289810771A5035472398 @default.
• W2289810771 hasAuthorship W2289810771A5055704415 @default.
• W2289810771 hasBestOaLocation W22898107712 @default.
• W2289810771 hasConcept C104317684 @default.
• W2289810771 hasConcept C107824862 @default.
• W2289810771 hasConcept C123298856 @default.
• W2289810771 hasConcept C138885662 @default.
• W2289810771 hasConcept C153911025 @default.
• W2289810771 hasConcept C159654299 @default.
• W2289810771 hasConcept C2778453870 @default.
• W2289810771 hasConcept C2778724333 @default.
• W2289810771 hasConcept C41895202 @default.
• W2289810771 hasConcept C54355233 @default.
• W2289810771 hasConcept C81885089 @default.
• W2289810771 hasConcept C86339819 @default.
• W2289810771 hasConcept C86803240 @default.
• W2289810771 hasConceptScore W2289810771C104317684 @default.
• W2289810771 hasConceptScore W2289810771C107824862 @default.
• W2289810771 hasConceptScore W2289810771C123298856 @default.
• W2289810771 hasConceptScore W2289810771C138885662 @default.
• W2289810771 hasConceptScore W2289810771C153911025 @default.
• W2289810771 hasConceptScore W2289810771C159654299 @default.
• W2289810771 hasConceptScore W2289810771C2778453870 @default.
• W2289810771 hasConceptScore W2289810771C2778724333 @default.
• W2289810771 hasConceptScore W2289810771C41895202 @default.
• W2289810771 hasConceptScore W2289810771C54355233 @default.
• W2289810771 hasConceptScore W2289810771C81885089 @default.

• next