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- W229008488 abstract "To investigate the expression of miR-223 in clear cell renal cell carcinoma (ccRcc) and its clinical implications.Quantitative real-time PCR was employed to detect the levels of miR- 223 expression in ccRcc, pair-matched adjacent normal tissues and different renal cancer cell lines. Transwell migration essay and wound healing essay were used to evaluate the invasion and migration of renal cancer 786-O cells transfected with miR-223 mimics. MTT essay was used to measure the cell proliferation, and the cell cycle changes following the transfection were analyzed with flow cytometry.Compared with the normal tissues, the cancer samples showed up-regulated miR-223 expression, which was associated with tumor size. In 786-O cell cultures, transfection with miR-223 mimics significantly enhanced cell migration (P<0.0001) and growth (P=0.006) and induced G1 cell cycle arrest.miR-223 promotes renal cancer cell migration and proliferation and may serve as a potential therapeutic target for ccRcc." @default.
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- W229008488 date "2015-03-01" @default.
- W229008488 modified "2023-09-30" @default.
- W229008488 title "[Expression of miR-223 in clear cell renal cell carcinoma and its significance]." @default.
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