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- W2290108081 abstract "Excess of reactive oxygen species (ROS) is increasingly recognized as a key factor in seizure-induced neuronal damage. Thus, targeting ROS is a priority to prevent seizures and epilepsy comorbidities such as cognitive decline, which are largely driven by neuronal damage. One drawback of this approach is that moderate levels of ROS are important in physiological cellular function and adaptation. This may also explain why antioxidant strategies targeting the brain have largely been unsuccessful. To overcome this difficulty, more fine-tuned ROS suppression in epilepsy is warranted. To achieve this goal, it is necessary to identify the key producers of ROS in seizures and epilepsy. Recent studies show that NADPH oxidase and xanthine oxidase are enzymes generating ROS in settings where energy metabolism is high, such as seen during seizure activity. An alternative approach is by targeting inducible networks of cellular antioxidant defences such as the Keap1–Nrf2 system. Nrf2 has emerged as a powerful regulator of endogenous antioxidant defences, and one drug (dimethyl fumarate) activating the Nrf2 pathway is already in use in inflammatory central nervous system (CNS) diseases. Both targeting key producers of ROS during seizure activity and Nrf2-enhancing strategies represent exciting new avenues of drug discovery in epilepsy." @default.
- W2290108081 created "2016-06-24" @default.
- W2290108081 creator A5053120398 @default.
- W2290108081 creator A5065525659 @default.
- W2290108081 creator A5083318259 @default.
- W2290108081 date "2016-01-01" @default.
- W2290108081 modified "2023-10-04" @default.
- W2290108081 title "The Role of Reactive Oxygen Species in Epilepsy" @default.
- W2290108081 cites W1482023004 @default.
- W2290108081 cites W1487436972 @default.
- W2290108081 cites W1522676079 @default.
- W2290108081 cites W1553877517 @default.
- W2290108081 cites W1584138159 @default.
- W2290108081 cites W1587552733 @default.
- W2290108081 cites W1602049707 @default.
- W2290108081 cites W1683287975 @default.
- W2290108081 cites W1813230101 @default.
- W2290108081 cites W1925799544 @default.
- W2290108081 cites W1964004644 @default.
- W2290108081 cites W1966830269 @default.
- W2290108081 cites W1969430202 @default.
- W2290108081 cites W1972317764 @default.
- W2290108081 cites W1972959301 @default.
- W2290108081 cites W1973882427 @default.
- W2290108081 cites W1978437325 @default.
- W2290108081 cites W1981558757 @default.
- W2290108081 cites W1982729063 @default.
- W2290108081 cites W1984475095 @default.
- W2290108081 cites W1986366581 @default.
- W2290108081 cites W1988593777 @default.
- W2290108081 cites W1991039871 @default.
- W2290108081 cites W1991707890 @default.
- W2290108081 cites W1993511165 @default.
- W2290108081 cites W2002894924 @default.
- W2290108081 cites W2004732690 @default.
- W2290108081 cites W2006823958 @default.
- W2290108081 cites W2007649442 @default.
- W2290108081 cites W2008656776 @default.
- W2290108081 cites W2011817526 @default.
- W2290108081 cites W2018334671 @default.
- W2290108081 cites W2018918340 @default.
- W2290108081 cites W2024984581 @default.
- W2290108081 cites W2025450822 @default.
- W2290108081 cites W2026275585 @default.
- W2290108081 cites W2027456968 @default.
- W2290108081 cites W2029790055 @default.
- W2290108081 cites W2031057169 @default.
- W2290108081 cites W2031283851 @default.
- W2290108081 cites W2034878415 @default.
- W2290108081 cites W2035676834 @default.
- W2290108081 cites W2039093344 @default.
- W2290108081 cites W2039126859 @default.
- W2290108081 cites W2040096357 @default.
- W2290108081 cites W2041182324 @default.
- W2290108081 cites W2041365749 @default.
- W2290108081 cites W2044284130 @default.
- W2290108081 cites W2049696886 @default.
- W2290108081 cites W2053047691 @default.
- W2290108081 cites W2056015556 @default.
- W2290108081 cites W2056620406 @default.
- W2290108081 cites W2057958542 @default.
- W2290108081 cites W2059378458 @default.
- W2290108081 cites W2059867715 @default.
- W2290108081 cites W2060522591 @default.
- W2290108081 cites W2061082432 @default.
- W2290108081 cites W2061260053 @default.
- W2290108081 cites W2063092399 @default.
- W2290108081 cites W2063340476 @default.
- W2290108081 cites W2064327102 @default.
- W2290108081 cites W2065397424 @default.
- W2290108081 cites W2066284829 @default.
- W2290108081 cites W2067842066 @default.
- W2290108081 cites W2070048444 @default.
- W2290108081 cites W2075229049 @default.
- W2290108081 cites W2075557750 @default.
- W2290108081 cites W2080716895 @default.
- W2290108081 cites W2083291313 @default.
- W2290108081 cites W2084299658 @default.
- W2290108081 cites W2084644507 @default.
- W2290108081 cites W2085128107 @default.
- W2290108081 cites W2087686750 @default.
- W2290108081 cites W2088105132 @default.
- W2290108081 cites W2088107588 @default.
- W2290108081 cites W2089032508 @default.
- W2290108081 cites W2093009907 @default.
- W2290108081 cites W2094039864 @default.
- W2290108081 cites W2094844253 @default.
- W2290108081 cites W2097634036 @default.
- W2290108081 cites W2097744068 @default.
- W2290108081 cites W2099792161 @default.
- W2290108081 cites W2103700558 @default.
- W2290108081 cites W2104380573 @default.
- W2290108081 cites W2106090126 @default.
- W2290108081 cites W2106466768 @default.
- W2290108081 cites W2108526545 @default.
- W2290108081 cites W2114931140 @default.
- W2290108081 cites W2115338196 @default.
- W2290108081 cites W2117966002 @default.
- W2290108081 cites W2124914820 @default.
- W2290108081 cites W2127705453 @default.