FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2290243397> ?p ?o ?g. }

• W2290243397 endingPage "13741" @default.
• W2290243397 startingPage "13730" @default.
• W2290243397 abstract "The more accurate biomarkers have long been desired for hepatocellular carcinoma (HCC). Here, we characterized global large-scale proteomics of multistep hepatocarcinogenesis in an attempt to identify novel biomarkers for HCC. Quantitative data of 37874 sequences and 3017 proteins during hepatocarcinogenesis were obtained in cohort 1 of 75 samples (5 pooled groups: normal livers, hepatitis livers, cirrhotic livers, peritumoral livers, and HCC tissues) by iTRAQ 2D LC-MS/MS. The diagnostic performance of the top six most upregulated proteins in HCC group and HSP70 as reference were subsequently validated in cohort 2 of 114 samples (hepatocarcinogenesis from normal livers to HCC) using immunohistochemistry. Of seven candidate protein markers, PARP1, GS and NDRG1 showed the optimal diagnostic performance for HCC. PARP1, as a novel marker, showed comparable diagnostic performance to that of classic markers GS and NDRG1 in HCC (AUCs = 0.872, 0.856 and 0.792, respectively). A significant higher AUC of 0.945 was achieved when three markers combined. For diagnosis of HCC, the sensitivity and specificity were 88.2% and 81.0% when at least two of the markers were positive. Similar diagnostic values of PARP1, GS and NDRG1 were confirmed by immunohistochemistry in cohort 3 of 180 HCC patients. Further analysis indicated that PARP1 and NDRG1 were associated with some clinicopathological features, and the independent prognostic factors for HCC patients. Overall, global large-scale proteomics on spectrum of multistep hepatocarcinogenesis are obtained. PARP1 is a novel promising diagnostic/prognostic marker for HCC, and the three-marker panel (PARP1, GS and NDRG1) with excellent diagnostic performance for HCC was established." @default.
• W2290243397 created "2016-06-24" @default.
• W2290243397 creator A5009926141 @default.
• W2290243397 creator A5011486049 @default.
• W2290243397 creator A5012309357 @default.
• W2290243397 creator A5032048736 @default.
• W2290243397 creator A5069972187 @default.
• W2290243397 creator A5081006802 @default.
• W2290243397 creator A5090012174 @default.
• W2290243397 date "2016-02-11" @default.
• W2290243397 modified "2023-10-16" @default.
• W2290243397 title "Global proteomic profiling in multistep hepatocarcinogenesis and identification of PARP1 as a novel molecular marker in hepatocellular carcinoma" @default.
• W2290243397 cites W1525804132 @default.
• W2290243397 cites W1563136310 @default.
• W2290243397 cites W1715823723 @default.
• W2290243397 cites W1836273607 @default.
• W2290243397 cites W1970028262 @default.
• W2290243397 cites W1983445012 @default.
• W2290243397 cites W1998948370 @default.
• W2290243397 cites W2014892573 @default.
• W2290243397 cites W2032630302 @default.
• W2290243397 cites W2047039797 @default.
• W2290243397 cites W2057526370 @default.
• W2290243397 cites W2062568615 @default.
• W2290243397 cites W2064024065 @default.
• W2290243397 cites W2065756821 @default.
• W2290243397 cites W2070047359 @default.
• W2290243397 cites W2092813388 @default.
• W2290243397 cites W2105154348 @default.
• W2290243397 cites W2110379988 @default.
• W2290243397 cites W2111191898 @default.
• W2290243397 cites W2112506082 @default.
• W2290243397 cites W2112776492 @default.
• W2290243397 cites W2114260929 @default.
• W2290243397 cites W2124535107 @default.
• W2290243397 cites W2151305493 @default.
• W2290243397 cites W2159791610 @default.
• W2290243397 cites W2172145344 @default.
• W2290243397 cites W2400726158 @default.
• W2290243397 cites W4211026375 @default.
• W2290243397 cites W1600477018 @default.
• W2290243397 doi "https://doi.org/10.18632/oncotarget.7316" @default.
• W2290243397 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4924674" @default.
• W2290243397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26883192" @default.
• W2290243397 hasPublicationYear "2016" @default.
• W2290243397 type Work @default.
• W2290243397 sameAs 2290243397 @default.
• W2290243397 citedByCount "16" @default.
• W2290243397 countsByYear W22902433972016 @default.
• W2290243397 countsByYear W22902433972017 @default.
• W2290243397 countsByYear W22902433972018 @default.
• W2290243397 countsByYear W22902433972020 @default.
• W2290243397 countsByYear W22902433972021 @default.
• W2290243397 countsByYear W22902433972023 @default.
• W2290243397 crossrefType "journal-article" @default.
• W2290243397 hasAuthorship W2290243397A5009926141 @default.
• W2290243397 hasAuthorship W2290243397A5011486049 @default.
• W2290243397 hasAuthorship W2290243397A5012309357 @default.
• W2290243397 hasAuthorship W2290243397A5032048736 @default.
• W2290243397 hasAuthorship W2290243397A5069972187 @default.
• W2290243397 hasAuthorship W2290243397A5081006802 @default.
• W2290243397 hasAuthorship W2290243397A5090012174 @default.
• W2290243397 hasBestOaLocation W22902433971 @default.
• W2290243397 hasConcept C121608353 @default.
• W2290243397 hasConcept C126322002 @default.
• W2290243397 hasConcept C142724271 @default.
• W2290243397 hasConcept C143998085 @default.
• W2290243397 hasConcept C204232928 @default.
• W2290243397 hasConcept C2778019345 @default.
• W2290243397 hasConcept C2780521871 @default.
• W2290243397 hasConcept C2781197716 @default.
• W2290243397 hasConcept C502942594 @default.
• W2290243397 hasConcept C55493867 @default.
• W2290243397 hasConcept C71924100 @default.
• W2290243397 hasConcept C86803240 @default.
• W2290243397 hasConceptScore W2290243397C121608353 @default.
• W2290243397 hasConceptScore W2290243397C126322002 @default.
• W2290243397 hasConceptScore W2290243397C142724271 @default.
• W2290243397 hasConceptScore W2290243397C143998085 @default.
• W2290243397 hasConceptScore W2290243397C204232928 @default.
• W2290243397 hasConceptScore W2290243397C2778019345 @default.
• W2290243397 hasConceptScore W2290243397C2780521871 @default.
• W2290243397 hasConceptScore W2290243397C2781197716 @default.
• W2290243397 hasConceptScore W2290243397C502942594 @default.
• W2290243397 hasConceptScore W2290243397C55493867 @default.
• W2290243397 hasConceptScore W2290243397C71924100 @default.
• W2290243397 hasConceptScore W2290243397C86803240 @default.
• W2290243397 hasIssue "12" @default.
• W2290243397 hasLocation W22902433971 @default.
• W2290243397 hasLocation W22902433972 @default.
• W2290243397 hasLocation W22902433973 @default.
• W2290243397 hasLocation W22902433974 @default.
• W2290243397 hasOpenAccess W2290243397 @default.
• W2290243397 hasPrimaryLocation W22902433971 @default.
• W2290243397 hasRelatedWork W2138198379 @default.
• W2290243397 hasRelatedWork W2359625386 @default.
• W2290243397 hasRelatedWork W2387944348 @default.
• W2290243397 hasRelatedWork W2394181844 @default.

• next