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- W2290347228 abstract "The non-covalent interactions of biological molecules provide the flexibility and specificity required in most important bioprocesses 1 • These non-covalent interactions especially intramolecular stacking interactions between the purine moiety of nucleotides and the aromatic rings of secondary ligands, viz., 2, 2'-bipyridine amino acids etc, has been the subject matter of several investigations 2 5 . The influence of aromatic ring stacking has been proved to be responsible for the enhancement of stability in ternary complexes in solution. At biological pH, these interactions determine th e efficiency and specificity of such processes as interaction occurring in proteins, enzymes, DNA and RNA. Therefore, more and more information is needed for better understanding. The present paper, which provides useful information regarding the stability and thermodynamic aspects of these interactions, is an endeavour in this direction . The Ni(II) was chosen since th e bioinorganic chemistry of Ni(II) is gaining importance because of its antineoplastic and carcinogenitic activity of its complexes610 and also the data with this metal is relatively scant. The paper details the study on the interaction of Ni(II) with purine nucleotides viz GMP, IMP (5'-monophosphates of guanosine and inosine respectively) and dipeptides (DL- alanyl-alanine and alanyl-phenylalanine) (Chart-l). Since GMP differs from IMP by way of having an additional exocyclic substituent amino (NH2) at C(2) position, this study al so provides an opportunity to assess the influence of exocyclic substituent on the stabilities . Among the dipeptides, alanyl-alanine being the simplest was 1}" @default.
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- W2290347228 date "2000-01-01" @default.
- W2290347228 modified "2023-09-27" @default.
- W2290347228 title "Interaction of Ni(II) with nucleotide:s and dipeptides - A quantitative study" @default.
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