FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2290361911> ?p ?o ?g. }

• W2290361911 endingPage "678" @default.
• W2290361911 startingPage "672" @default.
• W2290361911 abstract "ObjectiveTo determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA).DesignWomen between 50 and 60 years, with a BMI ≥27 kg/m2, free of knee OA, were recruited. Using binary logistic regression, the association between baseline concentration of serum fibulin (Fib)3-1, Fib3-2 and Fib3-3 and incidence of clinical and radiographic knee OA after 30 months of follow-up was evaluated.ResultsBaseline and follow-up measurements were available for 241 women with a mean age of 55.9 ± 3.2 years and mean BMI of 31.7 ± 3.6 kg/m2. None of the concentrations of the three Fib3 epitopes were associated with the incidence of medial or lateral joint space narrowing (JSN) ≥1.0 mm or the incidence of Kellgren & Lawrence (K&L) grade ≥2 after 30 months. All three Fib3 epitopes were associated with the incidence of the clinical and radiographic ACR-criteria and Fib3-1 and Fib3-3 also with chronic pain at follow-up. When adjusted for the other Fib3 peptide concentrations, only Fib3-1 was significantly associated to the incidence of the American College of Rheumatology (ACR)-criteria (OR 3.2 [1.2–8.7]) and chronic pain at follow-up (OR 3.0 [1.2–7.7]).ConclusionsBaseline fibulin-3 concentrations are associated with the incidence of clinical knee OA among middle-aged overweight and obese women. Therewith, they meet the criteria of a prognostic biomarker according to the BIPED biomarker classification for OA. Further validation of the fibulin-3 epitopes seems warranted in order to better distinguish subgroups of individuals at increased risk for knee OA development. To determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA). Women between 50 and 60 years, with a BMI ≥27 kg/m2, free of knee OA, were recruited. Using binary logistic regression, the association between baseline concentration of serum fibulin (Fib)3-1, Fib3-2 and Fib3-3 and incidence of clinical and radiographic knee OA after 30 months of follow-up was evaluated. Baseline and follow-up measurements were available for 241 women with a mean age of 55.9 ± 3.2 years and mean BMI of 31.7 ± 3.6 kg/m2. None of the concentrations of the three Fib3 epitopes were associated with the incidence of medial or lateral joint space narrowing (JSN) ≥1.0 mm or the incidence of Kellgren & Lawrence (K&L) grade ≥2 after 30 months. All three Fib3 epitopes were associated with the incidence of the clinical and radiographic ACR-criteria and Fib3-1 and Fib3-3 also with chronic pain at follow-up. When adjusted for the other Fib3 peptide concentrations, only Fib3-1 was significantly associated to the incidence of the American College of Rheumatology (ACR)-criteria (OR 3.2 [1.2–8.7]) and chronic pain at follow-up (OR 3.0 [1.2–7.7]). Baseline fibulin-3 concentrations are associated with the incidence of clinical knee OA among middle-aged overweight and obese women. Therewith, they meet the criteria of a prognostic biomarker according to the BIPED biomarker classification for OA. Further validation of the fibulin-3 epitopes seems warranted in order to better distinguish subgroups of individuals at increased risk for knee OA development." @default.
• W2290361911 created "2016-06-24" @default.
• W2290361911 creator A5012454701 @default.
• W2290361911 creator A5013980875 @default.
• W2290361911 creator A5040319350 @default.
• W2290361911 creator A5043214094 @default.
• W2290361911 creator A5055906881 @default.
• W2290361911 date "2016-04-01" @default.
• W2290361911 modified "2023-10-16" @default.
• W2290361911 title "Fibulin-3 fragments are prognostic biomarkers of osteoarthritis incidence in overweight and obese women" @default.
• W2290361911 cites W1560128605 @default.
• W2290361911 cites W1965665343 @default.
• W2290361911 cites W1967057044 @default.
• W2290361911 cites W1974511102 @default.
• W2290361911 cites W197462632 @default.
• W2290361911 cites W1977500066 @default.
• W2290361911 cites W1978598945 @default.
• W2290361911 cites W1992308020 @default.
• W2290361911 cites W1999472620 @default.
• W2290361911 cites W2001911932 @default.
• W2290361911 cites W2014891618 @default.
• W2290361911 cites W2051150556 @default.
• W2290361911 cites W2058147305 @default.
• W2290361911 cites W2059670411 @default.
• W2290361911 cites W2061553421 @default.
• W2290361911 cites W2061870125 @default.
• W2290361911 cites W2081398021 @default.
• W2290361911 cites W2087708640 @default.
• W2290361911 cites W2127260850 @default.
• W2290361911 cites W2128614781 @default.
• W2290361911 cites W2131189959 @default.
• W2290361911 cites W2137510389 @default.
• W2290361911 cites W2141913691 @default.
• W2290361911 doi "https://doi.org/10.1016/j.joca.2015.10.013" @default.
• W2290361911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26521011" @default.
• W2290361911 hasPublicationYear "2016" @default.
• W2290361911 type Work @default.
• W2290361911 sameAs 2290361911 @default.
• W2290361911 citedByCount "19" @default.
• W2290361911 countsByYear W22903619112017 @default.
• W2290361911 countsByYear W22903619112018 @default.
• W2290361911 countsByYear W22903619112019 @default.
• W2290361911 countsByYear W22903619112020 @default.
• W2290361911 countsByYear W22903619112021 @default.
• W2290361911 countsByYear W22903619112022 @default.
• W2290361911 crossrefType "journal-article" @default.
• W2290361911 hasAuthorship W2290361911A5012454701 @default.
• W2290361911 hasAuthorship W2290361911A5013980875 @default.
• W2290361911 hasAuthorship W2290361911A5040319350 @default.
• W2290361911 hasAuthorship W2290361911A5043214094 @default.
• W2290361911 hasAuthorship W2290361911A5055906881 @default.
• W2290361911 hasBestOaLocation W22903619111 @default.
• W2290361911 hasConcept C120665830 @default.
• W2290361911 hasConcept C121332964 @default.
• W2290361911 hasConcept C126322002 @default.
• W2290361911 hasConcept C142724271 @default.
• W2290361911 hasConcept C185592680 @default.
• W2290361911 hasConcept C198451711 @default.
• W2290361911 hasConcept C204787440 @default.
• W2290361911 hasConcept C2776164576 @default.
• W2290361911 hasConcept C2780221984 @default.
• W2290361911 hasConcept C2780586474 @default.
• W2290361911 hasConcept C2781197716 @default.
• W2290361911 hasConcept C55493867 @default.
• W2290361911 hasConcept C61511704 @default.
• W2290361911 hasConcept C71924100 @default.
• W2290361911 hasConceptScore W2290361911C120665830 @default.
• W2290361911 hasConceptScore W2290361911C121332964 @default.
• W2290361911 hasConceptScore W2290361911C126322002 @default.
• W2290361911 hasConceptScore W2290361911C142724271 @default.
• W2290361911 hasConceptScore W2290361911C185592680 @default.
• W2290361911 hasConceptScore W2290361911C198451711 @default.
• W2290361911 hasConceptScore W2290361911C204787440 @default.
• W2290361911 hasConceptScore W2290361911C2776164576 @default.
• W2290361911 hasConceptScore W2290361911C2780221984 @default.
• W2290361911 hasConceptScore W2290361911C2780586474 @default.
• W2290361911 hasConceptScore W2290361911C2781197716 @default.
• W2290361911 hasConceptScore W2290361911C55493867 @default.
• W2290361911 hasConceptScore W2290361911C61511704 @default.
• W2290361911 hasConceptScore W2290361911C71924100 @default.
• W2290361911 hasIssue "4" @default.
• W2290361911 hasLocation W22903619111 @default.
• W2290361911 hasLocation W22903619112 @default.
• W2290361911 hasLocation W22903619113 @default.
• W2290361911 hasLocation W22903619114 @default.
• W2290361911 hasOpenAccess W2290361911 @default.
• W2290361911 hasPrimaryLocation W22903619111 @default.
• W2290361911 hasRelatedWork W1524377315 @default.
• W2290361911 hasRelatedWork W170556918 @default.
• W2290361911 hasRelatedWork W2009384425 @default.
• W2290361911 hasRelatedWork W2063325699 @default.
• W2290361911 hasRelatedWork W206606740 @default.
• W2290361911 hasRelatedWork W2137188394 @default.
• W2290361911 hasRelatedWork W2275480158 @default.
• W2290361911 hasRelatedWork W2556102127 @default.
• W2290361911 hasRelatedWork W3010418487 @default.
• W2290361911 hasRelatedWork W4310555330 @default.
• W2290361911 hasVolume "24" @default.

• next