FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2290392788> ?p ?o ?g. }

• W2290392788 endingPage "356" @default.
• W2290392788 startingPage "345" @default.
• W2290392788 abstract "Defects in nuclear architecture occur in a variety of diseases, however the fundamental mechanisms that control the internal structure of nuclei are poorly defined. Here we reveal that the cellular microenvironment has a profound influence on the global internal organization of nuclei in breast epithelia. A 3D microenvironment induces a prolonged but reversible form of cell cycle arrest that features many of the classical markers of cell senescence. This unique form of arrest is dependent on signaling from the external microenvironment through β1-integrins. It is concomitant with alterations in nuclear architecture that characterize the withdrawal from cell proliferation. Unexpectedly, following prolonged cell cycle arrest in 3D, the senescence-like state and associated reprogramming of nuclear architecture are freely reversible on altering the dimensionality of the cellular microenvironment. Breast epithelia can therefore maintain a proliferative plasticity that correlates with nuclear remodelling. However, the changes in nuclear architecture are cell lineage-specific and do not occur in fibroblasts, and moreover they are overcome in breast cancer cells." @default.
• W2290392788 created "2016-06-24" @default.
• W2290392788 creator A5022223788 @default.
• W2290392788 creator A5030272378 @default.
• W2290392788 creator A5047030424 @default.
• W2290392788 creator A5090729430 @default.
• W2290392788 date "2016-02-01" @default.
• W2290392788 modified "2023-10-18" @default.
• W2290392788 title "Cellular microenvironment controls the nuclear architecture of breast epithelia through β1-integrin" @default.
• W2290392788 cites W1529048149 @default.
• W2290392788 cites W1565166977 @default.
• W2290392788 cites W1573379797 @default.
• W2290392788 cites W1644172598 @default.
• W2290392788 cites W1748552538 @default.
• W2290392788 cites W1966639607 @default.
• W2290392788 cites W1970924670 @default.
• W2290392788 cites W1977389606 @default.
• W2290392788 cites W1983001876 @default.
• W2290392788 cites W1992806609 @default.
• W2290392788 cites W1993570130 @default.
• W2290392788 cites W2002373110 @default.
• W2290392788 cites W2002982362 @default.
• W2290392788 cites W2004403900 @default.
• W2290392788 cites W2004824571 @default.
• W2290392788 cites W2005664674 @default.
• W2290392788 cites W2010399610 @default.
• W2290392788 cites W2011761081 @default.
• W2290392788 cites W2014606667 @default.
• W2290392788 cites W2019199710 @default.
• W2290392788 cites W2019276374 @default.
• W2290392788 cites W2029696463 @default.
• W2290392788 cites W2032461554 @default.
• W2290392788 cites W2032464841 @default.
• W2290392788 cites W2033799985 @default.
• W2290392788 cites W2038653804 @default.
• W2290392788 cites W2044779040 @default.
• W2290392788 cites W2053256698 @default.
• W2290392788 cites W2054635074 @default.
• W2290392788 cites W2064038671 @default.
• W2290392788 cites W2074350232 @default.
• W2290392788 cites W2086244192 @default.
• W2290392788 cites W2089440868 @default.
• W2290392788 cites W2094941673 @default.
• W2290392788 cites W2097381572 @default.
• W2290392788 cites W2098549100 @default.
• W2290392788 cites W2098619103 @default.
• W2290392788 cites W2108861663 @default.
• W2290392788 cites W2112124900 @default.
• W2290392788 cites W2117717914 @default.
• W2290392788 cites W2119824668 @default.
• W2290392788 cites W2127084782 @default.
• W2290392788 cites W2127362646 @default.
• W2290392788 cites W2143165983 @default.
• W2290392788 cites W2332475794 @default.
• W2290392788 cites W4211071958 @default.
• W2290392788 doi "https://doi.org/10.1080/15384101.2015.1121354" @default.
• W2290392788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4943696" @default.
• W2290392788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26818565" @default.
• W2290392788 hasPublicationYear "2016" @default.
• W2290392788 type Work @default.
• W2290392788 sameAs 2290392788 @default.
• W2290392788 citedByCount "22" @default.
• W2290392788 countsByYear W22903927882016 @default.
• W2290392788 countsByYear W22903927882017 @default.
• W2290392788 countsByYear W22903927882018 @default.
• W2290392788 countsByYear W22903927882019 @default.
• W2290392788 countsByYear W22903927882020 @default.
• W2290392788 countsByYear W22903927882021 @default.
• W2290392788 countsByYear W22903927882023 @default.
• W2290392788 crossrefType "journal-article" @default.
• W2290392788 hasAuthorship W2290392788A5022223788 @default.
• W2290392788 hasAuthorship W2290392788A5030272378 @default.
• W2290392788 hasAuthorship W2290392788A5047030424 @default.
• W2290392788 hasAuthorship W2290392788A5090729430 @default.
• W2290392788 hasBestOaLocation W22903927881 @default.
• W2290392788 hasConcept C121608353 @default.
• W2290392788 hasConcept C1491633281 @default.
• W2290392788 hasConcept C195687474 @default.
• W2290392788 hasConcept C2776107976 @default.
• W2290392788 hasConcept C29537977 @default.
• W2290392788 hasConcept C522857546 @default.
• W2290392788 hasConcept C54355233 @default.
• W2290392788 hasConcept C62112901 @default.
• W2290392788 hasConcept C77255625 @default.
• W2290392788 hasConcept C86803240 @default.
• W2290392788 hasConcept C95444343 @default.
• W2290392788 hasConceptScore W2290392788C121608353 @default.
• W2290392788 hasConceptScore W2290392788C1491633281 @default.
• W2290392788 hasConceptScore W2290392788C195687474 @default.
• W2290392788 hasConceptScore W2290392788C2776107976 @default.
• W2290392788 hasConceptScore W2290392788C29537977 @default.
• W2290392788 hasConceptScore W2290392788C522857546 @default.
• W2290392788 hasConceptScore W2290392788C54355233 @default.
• W2290392788 hasConceptScore W2290392788C62112901 @default.
• W2290392788 hasConceptScore W2290392788C77255625 @default.
• W2290392788 hasConceptScore W2290392788C86803240 @default.
• W2290392788 hasConceptScore W2290392788C95444343 @default.
• W2290392788 hasIssue "3" @default.

• next