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• W2290417719 abstract "Summary Cerebrospinal fluid (CSF) from subarachnoid haemorrhage (SAH) patients can stimulate vascular smooth muscle to generate force in vitro. CSF from SAH patients suering from delayed is- chaemic neurological deficits due to cerebral vasospasm can generate near maximal force in vitro and previous experiments have ascribed this generation of force to be a calcium mediated event. The intra- cellular calcium concentration has been demonstrated to rise during the vasospastic process. Calcium also stimulates oxidative metabo- lism as does adenosine diphosphate (ADP), the product of adenosine triphosphate (ATP) hydrolysis. Significant alteration in high energy metabolites such as ATP, ADP and phosphocreatine have also been demonstrated in various models of SAH mediated vasospasm. Vas- cular smooth muscle predominantly uses oxidative metabolism for force generation and reserves glycolytic metabolism for ion homeo- stasis. A decrease in oxidative metabolism during force generation would imply failing mitochondria and increased glycolytic high- energy phosphate supply. Increased oxidative metabolism would imply a decreased e‰ciency of the contractile apparatus or mitochondria. The aim of this study was to see if SAH CSF stimulation of por- cine carotid artery oxidative metabolism was altered during force generation when compared with incremental calcium stimulation with potassium chloride depolarisation. CSF from patientsOna 10U who had subarachnoid haemorrhage stimulated force generation but with a significant 'right shift' in oxygen consumption. This 'right shift' is indicative of an increased energy cost for contractile work. These results suggest that vascular smooth muscle contractile appa- ratus, when stimulated by subarachnoid cerebrospinal fluid, is con- suming excess adenosine triphosphate during force generation." @default.
• W2290417719 created "2016-06-24" @default.
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• W2290417719 date "2001-01-01" @default.
• W2290417719 modified "2023-09-27" @default.
• W2290417719 title "Experimental Research Cerebrospinal Fluid from Subarachnoid Haemorrhage Patients Causes Excessive Oxidative Metabolism Compared to Vascular Smooth Muscle Force Generation" @default.
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• W2290417719 hasPublicationYear "2001" @default.
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