Matches in SemOpenAlex for { <https://semopenalex.org/work/W2290469324> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W2290469324 abstract "Treating injured tissue with negative pressure re-establishes physiologic homeostasis and improves tissue survival. Injury sustained following reperfusion of ischemic myocardium involves processes similar to those seen after burns and other wounds. This study explores the possibility of using a mechanical device to achieve local resuscitation of myocardial tissue following acute myocardial infarction. Anesthetized swine were subjected to 75 min of left coronary artery occlusion and 3 hours of reperfusion. Animals were assigned to 1 of 3 groups: (1) control, treatment with (2) 50 mmHg or (3) 125 mmHg of MTR during reperfusion. All three groups were subjected to equivalent ischemic stress [area of risk (AAR) =12.9± 1.2%, 11.8±1.2% and 11.9±1.4%, respectively]. The application of MTR directly to the injured myocardium for 180 minutes significantly (p<0.001) reduced infarct size in both treatment groups compared to control: 9.3±1.8% (50 mm Hg) vs 26.4±2.1% (control); and 11.9±1.2% (125 mm Hg) vs 26.4±2.1% (control). Application of a controlled vacuum device directly to the injured myocardium for a defined period of time can achieve MTR and reduce tissue death after ischemia and reperfusion. This treatment strategy offers a simple, effective, clinically relevant, non-pharmacologic approach to reducing myocardial injury following ischemia and reperfusion." @default.
- W2290469324 created "2016-06-24" @default.
- W2290469324 creator A5011991148 @default.
- W2290469324 creator A5033554827 @default.
- W2290469324 creator A5061642533 @default.
- W2290469324 creator A5067934996 @default.
- W2290469324 creator A5075468805 @default.
- W2290469324 date "2009-04-01" @default.
- W2290469324 modified "2023-09-27" @default.
- W2290469324 title "Mechanical Tissue Resuscitation (MTR) Reduces Myocardial Reperfusion Injury" @default.
- W2290469324 doi "https://doi.org/10.1096/fasebj.23.1_supplement.793.1" @default.
- W2290469324 hasPublicationYear "2009" @default.
- W2290469324 type Work @default.
- W2290469324 sameAs 2290469324 @default.
- W2290469324 citedByCount "0" @default.
- W2290469324 crossrefType "journal-article" @default.
- W2290469324 hasAuthorship W2290469324A5011991148 @default.
- W2290469324 hasAuthorship W2290469324A5033554827 @default.
- W2290469324 hasAuthorship W2290469324A5061642533 @default.
- W2290469324 hasAuthorship W2290469324A5067934996 @default.
- W2290469324 hasAuthorship W2290469324A5075468805 @default.
- W2290469324 hasConcept C164705383 @default.
- W2290469324 hasConcept C2778165595 @default.
- W2290469324 hasConcept C2780114680 @default.
- W2290469324 hasConcept C2911020856 @default.
- W2290469324 hasConcept C42219234 @default.
- W2290469324 hasConcept C541997718 @default.
- W2290469324 hasConcept C71924100 @default.
- W2290469324 hasConceptScore W2290469324C164705383 @default.
- W2290469324 hasConceptScore W2290469324C2778165595 @default.
- W2290469324 hasConceptScore W2290469324C2780114680 @default.
- W2290469324 hasConceptScore W2290469324C2911020856 @default.
- W2290469324 hasConceptScore W2290469324C42219234 @default.
- W2290469324 hasConceptScore W2290469324C541997718 @default.
- W2290469324 hasConceptScore W2290469324C71924100 @default.
- W2290469324 hasIssue "S1" @default.
- W2290469324 hasLocation W22904693241 @default.
- W2290469324 hasOpenAccess W2290469324 @default.
- W2290469324 hasPrimaryLocation W22904693241 @default.
- W2290469324 hasRelatedWork W1502850201 @default.
- W2290469324 hasRelatedWork W2044803523 @default.
- W2290469324 hasRelatedWork W2058844431 @default.
- W2290469324 hasRelatedWork W2116277385 @default.
- W2290469324 hasRelatedWork W2167908781 @default.
- W2290469324 hasRelatedWork W2317480448 @default.
- W2290469324 hasRelatedWork W2471155155 @default.
- W2290469324 hasRelatedWork W2772442258 @default.
- W2290469324 hasRelatedWork W2950985218 @default.
- W2290469324 hasRelatedWork W2467927387 @default.
- W2290469324 hasVolume "23" @default.
- W2290469324 isParatext "false" @default.
- W2290469324 isRetracted "false" @default.
- W2290469324 magId "2290469324" @default.
- W2290469324 workType "article" @default.