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• W2290486499 abstract "In a subgroup of patients with systemic sclerosis (SSc), vasospasm affecting the pulmonary circulation may contribute to worsening respiratory symptoms, including dyspnea. Noninvasive assessment of pulmonary blood flow (PBF), utilizing inert‐gas rebreathing (IGR) and dual‐energy computed‐tomography pulmonary angiography (DE‐CTPA), may be useful for identifying pulmonary vasospasm. Thirty‐one participants (22 SSc patients and 9 healthy volunteers) underwent PBF assessment with IGR and DE‐CTPA at baseline and after provocation with a cold‐air inhalation challenge (CACh). Before the study investigations, participants were assigned to subgroups: group A included SSc patients who reported increased breathlessness after exposure to cold air ( n = 11), group B included SSc patients without cold‐air sensitivity ( n = 11), and group C patients included the healthy volunteers. Median change in PBF from baseline was compared between groups A, B, and C after CACh. Compared with groups B and C, in group A there was a significant decline in median PBF from baseline at 10 minutes (−10%; range: −52.2% to 4.0%; P < 0.01), 20 minutes (−17.4%; −27.9% to 0.0%; P < 0.01), and 30 minutes (−8.5%; −34.4% to 2.0%; P < 0.01) after CACh. There was no significant difference in median PBF change between groups B or C at any time point and no change in pulmonary perfusion on DE‐CTPA. Reduction in pulmonary blood flow following CACh suggests that pulmonary vasospasm may be present in a subgroup of patients with SSc and may contribute to worsening dyspnea on exposure to cold." @default.
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• W2290486499 date "2015-09-01" @default.
• W2290486499 modified "2023-10-10" @default.
• W2290486499 title "Pulmonary Vasospasm in Systemic Sclerosis: Noninvasive Techniques for Detection" @default.
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• W2290486499 doi "https://doi.org/10.1086/682221" @default.
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