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- W2290492094 abstract "Introduction: Postsurgical pain is the main cause of acute pain in hospital settings. Selective α-2 adrenergic agonists such as clonidine and dexmedetomidine administered via peridural infusion have been evaluated in postsurgical pain control, since they act on brain stem, spinal and peripheral receptors, modulating the nociceptive input. In this context, clonidine is the most studied drug, but little information exists with dexmedetomidine. Objective: To evaluate the efficacy of the add-on use of dexmedetomidine in peridural anesthesia, as a strategy aimed to diminish postsurgical pain. Methods: An open-label trial was designed to com- pare bupivacaine via 24-h peridural infusion (n = 15) versus the combination of bupivacaine and dexmedetomidine (Bupi/Dexme, n = 21) in women who underwent abdominal hysterectomy. The main study outcome was the magnitude of postsurgical pain (as reflected in a visual analog scale) and the need for rescue analgesia during 24 h of peridural infusion after surgery. We also evaluated the impact on heart rate" @default.
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- W2290492094 date "2011-01-01" @default.
- W2290492094 modified "2023-10-18" @default.
- W2290492094 title "Dexmedetomidina más bupivacaína frente a bupivacaína sola en infusión peridural para el control del dolor postquirúrgico" @default.
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