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• W2290497402 abstract "SUMMARY Taurine, a sulfur containing amino acid, is abundant in many organs and tissues in mammals!. However, its physiological significance has been hardly understood. We reported that daily urinary taurine excretion significantly decreased in patients with essential hypertension, and administration of taurine increased urinary kallikrein and decreased blood pressure2 • In the field of experimental hypertension animal, administration of taurine also showed antihypertensive effect in spontaneously hypertensive rats (SHR)3 and in a stroke-prone substrain (SHR-SP)4, in which the deficiency of taurine metabolism was demonstrated 3,5. Since urinary kallikrein has a positive correlation with urinary kinin 6 , it seems that taurine stimulates kallikrein activity to increase the quantity of kinin produced in the kidney. Our hypothesis in the kidney is that taurine has a natriuretic action due to stimulation of the renal kallikrein-kinin (K-K) system and renal prostaglandin system. The purpose of the present study is to examine the effect of taurine on natriuresis in rats with normal, high and low salt diets, which is related to stimulation in the K-K and prostaglandin system in the kidney." @default.
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• W2290497402 date "1989-01-01" @default.
• W2290497402 modified "2023-09-28" @default.
• W2290497402 title "ENDOTHELIAL AND SMOOTH MUSCLE CELLS" @default.
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