FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2290581453> ?p ?o ?g. }

• W2290581453 endingPage "3668" @default.
• W2290581453 startingPage "3662" @default.
• W2290581453 abstract "Inspired by the structural and functional features of proteins in cell signaling, a switchable peptide is designed in this work. This switchable peptide is named a “peptamer,” and it can react to ligand binding with conformational change and activation/deactivation of catalytic ability. The peptamer is constructed by elaborately integrating several different peptide motifs with targeting and catalytic abilities. Thus, targeted binding of the peptamer to an integrin can be regulated by a synthetic ligand. Moreover, the conformational rearrangement of the peptamer induced by both integrin and the synthetic ligand can resolve in altered affinity of the peptamer for a catalytic cofactor, cupric ion. This leads to greatly contrasted efficiency of catalysis in the presence/absence of integrin. This distinct switching on/off of catalytic activity also enables a bioassay of tissue integrin expression in clinical samples of thyroid carcinoma. Experimental results reveal that the detected integrin level parallels the state of lymph node metastasis. Therefore, this simple peptide model may help to understand the structural reconfiguration of proteins involved in cellular signal transduction, as well as to provide a new means to assess protein activity under pathological conditions such as cancer." @default.
• W2290581453 created "2016-06-24" @default.
• W2290581453 creator A5019560977 @default.
• W2290581453 creator A5026106759 @default.
• W2290581453 creator A5047139347 @default.
• W2290581453 creator A5052372115 @default.
• W2290581453 creator A5074934997 @default.
• W2290581453 creator A5082180266 @default.
• W2290581453 date "2016-03-14" @default.
• W2290581453 modified "2023-10-15" @default.
• W2290581453 title "Detection of Tumor Invasive Biomarker using a Peptamer of Signal Conversion and Signal Amplification" @default.
• W2290581453 cites W1498892177 @default.
• W2290581453 cites W1589425267 @default.
• W2290581453 cites W1599373893 @default.
• W2290581453 cites W1976292255 @default.
• W2290581453 cites W1979522770 @default.
• W2290581453 cites W2009339798 @default.
• W2290581453 cites W2013050330 @default.
• W2290581453 cites W2023002339 @default.
• W2290581453 cites W2024759858 @default.
• W2290581453 cites W2041372545 @default.
• W2290581453 cites W2047943796 @default.
• W2290581453 cites W2052594402 @default.
• W2290581453 cites W2057247058 @default.
• W2290581453 cites W2060179431 @default.
• W2290581453 cites W2065097700 @default.
• W2290581453 cites W2074070818 @default.
• W2290581453 cites W2090659127 @default.
• W2290581453 cites W2094337993 @default.
• W2290581453 cites W2098789742 @default.
• W2290581453 cites W2119921227 @default.
• W2290581453 cites W2136471260 @default.
• W2290581453 cites W2149682926 @default.
• W2290581453 cites W2159765576 @default.
• W2290581453 cites W2166269098 @default.
• W2290581453 cites W2166634773 @default.
• W2290581453 cites W2323845239 @default.
• W2290581453 cites W2325710774 @default.
• W2290581453 cites W2331658744 @default.
• W2290581453 doi "https://doi.org/10.1021/acs.analchem.5b04423" @default.
• W2290581453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26938572" @default.
• W2290581453 hasPublicationYear "2016" @default.
• W2290581453 type Work @default.
• W2290581453 sameAs 2290581453 @default.
• W2290581453 citedByCount "15" @default.
• W2290581453 countsByYear W22905814532016 @default.
• W2290581453 countsByYear W22905814532017 @default.
• W2290581453 countsByYear W22905814532019 @default.
• W2290581453 countsByYear W22905814532020 @default.
• W2290581453 countsByYear W22905814532021 @default.
• W2290581453 crossrefType "journal-article" @default.
• W2290581453 hasAuthorship W2290581453A5019560977 @default.
• W2290581453 hasAuthorship W2290581453A5026106759 @default.
• W2290581453 hasAuthorship W2290581453A5047139347 @default.
• W2290581453 hasAuthorship W2290581453A5052372115 @default.
• W2290581453 hasAuthorship W2290581453A5074934997 @default.
• W2290581453 hasAuthorship W2290581453A5082180266 @default.
• W2290581453 hasConcept C116569031 @default.
• W2290581453 hasConcept C12554922 @default.
• W2290581453 hasConcept C170493617 @default.
• W2290581453 hasConcept C185592680 @default.
• W2290581453 hasConcept C195687474 @default.
• W2290581453 hasConcept C2779281246 @default.
• W2290581453 hasConcept C55493867 @default.
• W2290581453 hasConcept C62478195 @default.
• W2290581453 hasConcept C86803240 @default.
• W2290581453 hasConcept C95444343 @default.
• W2290581453 hasConceptScore W2290581453C116569031 @default.
• W2290581453 hasConceptScore W2290581453C12554922 @default.
• W2290581453 hasConceptScore W2290581453C170493617 @default.
• W2290581453 hasConceptScore W2290581453C185592680 @default.
• W2290581453 hasConceptScore W2290581453C195687474 @default.
• W2290581453 hasConceptScore W2290581453C2779281246 @default.
• W2290581453 hasConceptScore W2290581453C55493867 @default.
• W2290581453 hasConceptScore W2290581453C62478195 @default.
• W2290581453 hasConceptScore W2290581453C86803240 @default.
• W2290581453 hasConceptScore W2290581453C95444343 @default.
• W2290581453 hasFunder F4320321001 @default.
• W2290581453 hasIssue "7" @default.
• W2290581453 hasLocation W22905814531 @default.
• W2290581453 hasLocation W22905814532 @default.
• W2290581453 hasLocation W22905814533 @default.
• W2290581453 hasLocation W22905814534 @default.
• W2290581453 hasOpenAccess W2290581453 @default.
• W2290581453 hasPrimaryLocation W22905814531 @default.
• W2290581453 hasRelatedWork W2058624823 @default.
• W2290581453 hasRelatedWork W2089517448 @default.
• W2290581453 hasRelatedWork W2433805774 @default.
• W2290581453 hasRelatedWork W2527276563 @default.
• W2290581453 hasRelatedWork W2978801098 @default.
• W2290581453 hasRelatedWork W3003854772 @default.
• W2290581453 hasRelatedWork W3005152597 @default.
• W2290581453 hasRelatedWork W4254002774 @default.
• W2290581453 hasRelatedWork W643188841 @default.
• W2290581453 hasRelatedWork W2752635221 @default.
• W2290581453 hasVolume "88" @default.
• W2290581453 isParatext "false" @default.
• W2290581453 isRetracted "false" @default.

• next