Matches in SemOpenAlex for { <https://semopenalex.org/work/W2290585899> ?p ?o ?g. }
- W2290585899 endingPage "226" @default.
- W2290585899 startingPage "217" @default.
- W2290585899 abstract "Buccal films were prepared from aqueous and ethanolic Metolose gels using the solvent casting approach (40 °C). The hydration (PBS and simulated saliva), mucoadhesion, physical stability (20 °C, 40 °C), in vitro drug (omeprazole) dissolution (PBS and simulated saliva), ex vivo permeation (pig buccal mucosa) in the presence of simulated saliva, ex vivo bioadhesion and cell viability using MTT of films were investigated. Hydration and mucoadhesion results showed that swelling capacity and adhesion was higher in the presence of PBS than simulated saliva (SS) due to differences in ionic strength. Omeprazole was more stable at 20 °C than 40 °C whilst omeprazole release reached a plateau within 1 h and faster in PBS than in SS. Fitting release data to kinetic models showed that Korsmeyer–Peppas equation best fit the dissolution data. Drug release in PBS was best described by zero order via non-Fickian diffusion but followed super case II transport in SS attributed to drug diffusion and polymer erosion. The amount of omeprazole permeating over 2 h was 275 ug/cm2 whilst the formulations and starting materials showed cell viability values greater than 95%, confirming their safety for potential use in paediatric buccal delivery." @default.
- W2290585899 created "2016-06-24" @default.
- W2290585899 creator A5014989635 @default.
- W2290585899 creator A5033241727 @default.
- W2290585899 creator A5040765488 @default.
- W2290585899 date "2016-03-01" @default.
- W2290585899 modified "2023-10-10" @default.
- W2290585899 title "Functional physico-chemical, ex vivo permeation and cell viability characterization of omeprazole loaded buccal films for paediatric drug delivery" @default.
- W2290585899 cites W1965141983 @default.
- W2290585899 cites W1980326170 @default.
- W2290585899 cites W1984323372 @default.
- W2290585899 cites W1984665113 @default.
- W2290585899 cites W1995984386 @default.
- W2290585899 cites W1999841728 @default.
- W2290585899 cites W2003504264 @default.
- W2290585899 cites W2008336471 @default.
- W2290585899 cites W2011172462 @default.
- W2290585899 cites W2020406291 @default.
- W2290585899 cites W2020924976 @default.
- W2290585899 cites W2024435874 @default.
- W2290585899 cites W2025463706 @default.
- W2290585899 cites W2026237079 @default.
- W2290585899 cites W2033006726 @default.
- W2290585899 cites W2036433758 @default.
- W2290585899 cites W2041880062 @default.
- W2290585899 cites W2043960485 @default.
- W2290585899 cites W2057306840 @default.
- W2290585899 cites W2059252785 @default.
- W2290585899 cites W2059279620 @default.
- W2290585899 cites W2064508865 @default.
- W2290585899 cites W2072951870 @default.
- W2290585899 cites W2073604987 @default.
- W2290585899 cites W2087496871 @default.
- W2290585899 cites W2088592669 @default.
- W2290585899 cites W2089268028 @default.
- W2290585899 cites W2090305500 @default.
- W2290585899 cites W2098880422 @default.
- W2290585899 cites W2112678521 @default.
- W2290585899 cites W2115439624 @default.
- W2290585899 cites W2130026714 @default.
- W2290585899 cites W2141657818 @default.
- W2290585899 cites W2157389358 @default.
- W2290585899 cites W2165387177 @default.
- W2290585899 cites W2168234648 @default.
- W2290585899 cites W2170965758 @default.
- W2290585899 cites W2188615024 @default.
- W2290585899 cites W2216174252 @default.
- W2290585899 cites W53488019 @default.
- W2290585899 doi "https://doi.org/10.1016/j.ijpharm.2016.01.045" @default.
- W2290585899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26802493" @default.
- W2290585899 hasPublicationYear "2016" @default.
- W2290585899 type Work @default.
- W2290585899 sameAs 2290585899 @default.
- W2290585899 citedByCount "32" @default.
- W2290585899 countsByYear W22905858992016 @default.
- W2290585899 countsByYear W22905858992017 @default.
- W2290585899 countsByYear W22905858992018 @default.
- W2290585899 countsByYear W22905858992019 @default.
- W2290585899 countsByYear W22905858992020 @default.
- W2290585899 countsByYear W22905858992021 @default.
- W2290585899 countsByYear W22905858992022 @default.
- W2290585899 countsByYear W22905858992023 @default.
- W2290585899 crossrefType "journal-article" @default.
- W2290585899 hasAuthorship W2290585899A5014989635 @default.
- W2290585899 hasAuthorship W2290585899A5033241727 @default.
- W2290585899 hasAuthorship W2290585899A5040765488 @default.
- W2290585899 hasBestOaLocation W22905858992 @default.
- W2290585899 hasConcept C13245373 @default.
- W2290585899 hasConcept C13965031 @default.
- W2290585899 hasConcept C150903083 @default.
- W2290585899 hasConcept C178790620 @default.
- W2290585899 hasConcept C185592680 @default.
- W2290585899 hasConcept C195735259 @default.
- W2290585899 hasConcept C202751555 @default.
- W2290585899 hasConcept C207001950 @default.
- W2290585899 hasConcept C26291073 @default.
- W2290585899 hasConcept C2777498785 @default.
- W2290585899 hasConcept C2779820397 @default.
- W2290585899 hasConcept C2780020223 @default.
- W2290585899 hasConcept C41625074 @default.
- W2290585899 hasConcept C43617362 @default.
- W2290585899 hasConcept C504460877 @default.
- W2290585899 hasConcept C50670333 @default.
- W2290585899 hasConcept C55493867 @default.
- W2290585899 hasConcept C71924100 @default.
- W2290585899 hasConcept C86803240 @default.
- W2290585899 hasConcept C88380143 @default.
- W2290585899 hasConcept C98274493 @default.
- W2290585899 hasConceptScore W2290585899C13245373 @default.
- W2290585899 hasConceptScore W2290585899C13965031 @default.
- W2290585899 hasConceptScore W2290585899C150903083 @default.
- W2290585899 hasConceptScore W2290585899C178790620 @default.
- W2290585899 hasConceptScore W2290585899C185592680 @default.
- W2290585899 hasConceptScore W2290585899C195735259 @default.
- W2290585899 hasConceptScore W2290585899C202751555 @default.
- W2290585899 hasConceptScore W2290585899C207001950 @default.
- W2290585899 hasConceptScore W2290585899C26291073 @default.
- W2290585899 hasConceptScore W2290585899C2777498785 @default.