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• W2290615087 abstract "The adaptive immune system functions efficiently to eliminate potential pathogens that escape innate host defenses. Unfortunately, defects of the adaptive system can result in overwhelming infections with a variety of microorganisms. These defects may be either congenital or acquired. Prior to the availability of antibiotics, sporadic observations of children with histories involving recurrent infections appeared in the French, German, and English literature. The first description of a congenital immunodeficiency disease is generally attributed to Col. Ogden Bruton in 1952 with his publication of a case report of an 8-year-old boy with X-linked agammaglobulinemia. Since 1952 a large number of patients with different congenital immunodeficiencies have been reported: these include failure of the thymus to develop or function properly, antigen-presenting cells that failed to HLA molecules, and individuals presenting with a total lack of both T and B lymphocyte-mediated immunity. All of these diseases are rare. Finally in 1981 a report of recurrent and unusual infections in a group of homosexual males ushered in the realization that immunodeficiency could be acquired as a result of a viral infection. The information obtained from the study of both congenital and acquired immunodeficiencies has provided a wealth of information about the development and functioning of the normal immune system." @default.
• W2290615087 created "2016-06-24" @default.
• W2290615087 creator A5030005877 @default.
• W2290615087 date "2016-01-01" @default.
• W2290615087 modified "2023-10-18" @default.
• W2290615087 title "Defects in the Adaptive Immune Response Leading to Recurrent Infections" @default.
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• W2290615087 doi "https://doi.org/10.1016/b978-0-12-398381-7.00032-0" @default.
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