FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2290697321> ?p ?o ?g. }

• W2290697321 endingPage "1021" @default.
• W2290697321 startingPage "1013" @default.
• W2290697321 abstract "ABSTRACT The ro tational s urveillance and e nergy t ransfer (ROSET) model of TonB action suggests a mechanism by which the electrochemical proton gradient across the Gram-negative bacterial inner membrane (IM) promotes the transport of iron through ligand-gated porins (LGP) in the outer membrane (OM). TonB associates with the IM by an N-terminal hydrophobic helix that forms a complex with ExbBD. It also contains a central extended length of rigid polypeptide that spans the periplasm and a dimeric C - t erminal-ββαβ- d omain (CTD) with LysM motifs that binds the peptidoglycan (PG) layer beneath the OM bilayer. The TonB CTD forms a dimer with affinity for both PG- and TonB-independent OM proteins (e.g., OmpA), localizing it near the periplasmic interface of the OM bilayer. Porins and other OM proteins associate with PG, and this general affinity allows the TonB CTD dimer to survey the periplasmic surface of the OM bilayer. Energized rotational motion of the TonB N terminus in the fluid IM bilayer promotes the lateral movement of the TonB-ExbBD complex in the IM and of the TonB CTD dimer across the inner surface of the OM. When it encounters an accessible TonB box of a (ligand-bound) LGP, the monomeric form of the CTD binds and recruits it into a 4-stranded β-sheet. Because the CTD is rotating, this binding reaction transfers kinetic energy, created by the electrochemical proton gradient across the IM, through the periplasm to the OM protein. The equilibration of the TonB C terminus between the dimeric and monomeric forms that engage in different binding reactions allows the identification of iron-loaded LGP and then the internalization of iron through their trans-outer membrane β-barrels. Hence, the ROSET model postulates a mechanism for the transfer of energy from the IM to the OM, triggering iron uptake." @default.
• W2290697321 created "2016-06-24" @default.
• W2290697321 creator A5025387192 @default.
• W2290697321 date "2016-04-01" @default.
• W2290697321 modified "2023-09-25" @default.
• W2290697321 title "ROSET Model of TonB Action in Gram-Negative Bacterial Iron Acquisition" @default.
• W2290697321 cites W1489162395 @default.
• W2290697321 cites W1515386059 @default.
• W2290697321 cites W1526887346 @default.
• W2290697321 cites W1538296334 @default.
• W2290697321 cites W1570409110 @default.
• W2290697321 cites W1581821440 @default.
• W2290697321 cites W1590827189 @default.
• W2290697321 cites W1597781843 @default.
• W2290697321 cites W1622268707 @default.
• W2290697321 cites W1648158953 @default.
• W2290697321 cites W1676178724 @default.
• W2290697321 cites W1848460403 @default.
• W2290697321 cites W1880069781 @default.
• W2290697321 cites W1902714978 @default.
• W2290697321 cites W1912992879 @default.
• W2290697321 cites W1943385732 @default.
• W2290697321 cites W1944845554 @default.
• W2290697321 cites W1963676019 @default.
• W2290697321 cites W1965600386 @default.
• W2290697321 cites W1967192516 @default.
• W2290697321 cites W1967351864 @default.
• W2290697321 cites W1968723178 @default.
• W2290697321 cites W1969795354 @default.
• W2290697321 cites W1971818490 @default.
• W2290697321 cites W1975943954 @default.
• W2290697321 cites W1986566018 @default.
• W2290697321 cites W1986709889 @default.
• W2290697321 cites W1993043960 @default.
• W2290697321 cites W1993645665 @default.
• W2290697321 cites W1995691868 @default.
• W2290697321 cites W2005091504 @default.
• W2290697321 cites W2006580038 @default.
• W2290697321 cites W2011268135 @default.
• W2290697321 cites W2011944885 @default.
• W2290697321 cites W2019082498 @default.
• W2290697321 cites W2019745465 @default.
• W2290697321 cites W2027403968 @default.
• W2290697321 cites W2029956246 @default.
• W2290697321 cites W2038511756 @default.
• W2290697321 cites W2039722695 @default.
• W2290697321 cites W2040665000 @default.
• W2290697321 cites W2042133316 @default.
• W2290697321 cites W2042303206 @default.
• W2290697321 cites W2045469817 @default.
• W2290697321 cites W2045786708 @default.
• W2290697321 cites W2052779789 @default.
• W2290697321 cites W205412000 @default.
• W2290697321 cites W2054241952 @default.
• W2290697321 cites W206775021 @default.
• W2290697321 cites W2068865225 @default.
• W2290697321 cites W2072340170 @default.
• W2290697321 cites W2072871401 @default.
• W2290697321 cites W2080040277 @default.
• W2290697321 cites W2083206262 @default.
• W2290697321 cites W2084608838 @default.
• W2290697321 cites W2085414979 @default.
• W2290697321 cites W2089980111 @default.
• W2290697321 cites W2093895466 @default.
• W2290697321 cites W2096277557 @default.
• W2290697321 cites W2096507065 @default.
• W2290697321 cites W2096650678 @default.
• W2290697321 cites W2098624375 @default.
• W2290697321 cites W2101820146 @default.
• W2290697321 cites W2102319161 @default.
• W2290697321 cites W2104176117 @default.
• W2290697321 cites W2105389904 @default.
• W2290697321 cites W2108623931 @default.
• W2290697321 cites W2115069651 @default.
• W2290697321 cites W2116910915 @default.
• W2290697321 cites W2119227949 @default.
• W2290697321 cites W2120061656 @default.
• W2290697321 cites W2121209974 @default.
• W2290697321 cites W2122334299 @default.
• W2290697321 cites W2126776054 @default.
• W2290697321 cites W2130630244 @default.
• W2290697321 cites W2133716242 @default.
• W2290697321 cites W2142692636 @default.
• W2290697321 cites W2143132616 @default.
• W2290697321 cites W2146769839 @default.
• W2290697321 cites W2147056018 @default.
• W2290697321 cites W2150740602 @default.
• W2290697321 cites W2151761446 @default.
• W2290697321 cites W2152608798 @default.
• W2290697321 cites W2154309648 @default.
• W2290697321 cites W2157498391 @default.
• W2290697321 cites W2161268253 @default.
• W2290697321 cites W2161819629 @default.
• W2290697321 cites W2166852006 @default.
• W2290697321 cites W2168417777 @default.
• W2290697321 cites W2231437427 @default.
• W2290697321 cites W2333624899 @default.
• W2290697321 cites W4235255487 @default.

• next