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- W2290697454 abstract "The locus control region (LCR) was first identified in the human β globin locus. It plays an important role of regulating gene expression in differentiation and development of erythrocyte. The LCR is located 6 - 25 kb upstream of the first globin gene and consists of 7 DNase I hypersensitive sites. The most prominent property of the LCR is their strong transcription-enhancing activity. LCR can also participate in histone modification, chromatin 'open', nuclear localization, domain boundaries formation, and timing and origin of DNA replication. Four models of LCR function have been proposed, while most of the experimental results support the looping model. Besides in β globin locus, LCRs are found in the loci of growth hormone, TH2 cytokine, MHCII and many other genes." @default.
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- W2290697454 date "2010-01-01" @default.
- W2290697454 modified "2023-09-23" @default.
- W2290697454 title "Gene expression regulated by locous control region" @default.
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