Matches in SemOpenAlex for { <https://semopenalex.org/work/W2290754495> ?p ?o ?g. }
- W2290754495 endingPage "331" @default.
- W2290754495 startingPage "323" @default.
- W2290754495 abstract "Ulcerative colitis (UC) is one of the two major forms of inflammatory bowel disease, the aetiology of which remains unknown. Several studies have demonstrated the genetic basis of disease, identifying more than 130 susceptibility loci. The major histocompatibility complex class I chain-related gene A (MICA) is a useful candidate to be involved in UC pathogenesis, because it could be important in recognizing the integrity of the epithelial cell and its response to stress. The aim of this study was to analyse the relationship between polymorphisms in the transmembrane domain of MICA and susceptibility to develop UC. A total of 340 patients with UC and 636 healthy controls were genotyped for MICA transmembrane polymorphism using a polymerase chain reaction (PCR) combined with fluorescent technology. Different MICA alleles were determined depending on the PCR product size. The allele MICA*A4 was less frequent in patients than in controls (P = 0·003; OR = 0·643), and this protective role is higher when it forms haplotype with B*27 (P = 0·002; OR = 0·294). The haplotype HLA-B*52/MICA*A6 was also associated with UC [P = 0·001; odds ratio (OR) = 2·914]. No other alleles, genotypes or haplotypes were related with UC risk. Moreover, MICA*A5.1 is associated independently with abscesses (P = 0·002; OR = 3·096) and its frequency is lower in patients diagnosed between ages 17 and 40 years (P = 0·007; OR = 0·633), meaning an extreme age on onset. No association with location, extra-intestinal manifestations or need for surgery was found." @default.
- W2290754495 created "2016-06-24" @default.
- W2290754495 creator A5013327092 @default.
- W2290754495 creator A5026694921 @default.
- W2290754495 creator A5069412319 @default.
- W2290754495 creator A5071366275 @default.
- W2290754495 creator A5073566037 @default.
- W2290754495 creator A5082237234 @default.
- W2290754495 date "2016-04-05" @default.
- W2290754495 modified "2023-10-18" @default.
- W2290754495 title "MICA*A4 protects against ulcerative colitis, whereas MICA*A5.1 is associated with abscess formation and age of onset" @default.
- W2290754495 cites W1495189347 @default.
- W2290754495 cites W1891283710 @default.
- W2290754495 cites W1963966961 @default.
- W2290754495 cites W1964066846 @default.
- W2290754495 cites W1964922876 @default.
- W2290754495 cites W1966581484 @default.
- W2290754495 cites W1971104055 @default.
- W2290754495 cites W1974620306 @default.
- W2290754495 cites W1981431265 @default.
- W2290754495 cites W1982780404 @default.
- W2290754495 cites W1985021053 @default.
- W2290754495 cites W1985526232 @default.
- W2290754495 cites W1985576417 @default.
- W2290754495 cites W1987644268 @default.
- W2290754495 cites W1988453120 @default.
- W2290754495 cites W1990075215 @default.
- W2290754495 cites W1991192475 @default.
- W2290754495 cites W1999191024 @default.
- W2290754495 cites W2000070744 @default.
- W2290754495 cites W2005314920 @default.
- W2290754495 cites W2010358055 @default.
- W2290754495 cites W2014240728 @default.
- W2290754495 cites W2014410947 @default.
- W2290754495 cites W2014864356 @default.
- W2290754495 cites W2015138096 @default.
- W2290754495 cites W2023770746 @default.
- W2290754495 cites W2029588174 @default.
- W2290754495 cites W2031077682 @default.
- W2290754495 cites W2035744694 @default.
- W2290754495 cites W2035757605 @default.
- W2290754495 cites W2036544142 @default.
- W2290754495 cites W2041832909 @default.
- W2290754495 cites W2044342378 @default.
- W2290754495 cites W2045752300 @default.
- W2290754495 cites W2050710502 @default.
- W2290754495 cites W2053374011 @default.
- W2290754495 cites W2056204715 @default.
- W2290754495 cites W2070110176 @default.
- W2290754495 cites W2076924907 @default.
- W2290754495 cites W2078621117 @default.
- W2290754495 cites W2091373607 @default.
- W2290754495 cites W2097804771 @default.
- W2290754495 cites W2098920847 @default.
- W2290754495 cites W2099183944 @default.
- W2290754495 cites W2112752664 @default.
- W2290754495 cites W2115588985 @default.
- W2290754495 cites W2119799171 @default.
- W2290754495 cites W2130699567 @default.
- W2290754495 cites W2141661308 @default.
- W2290754495 cites W2143625465 @default.
- W2290754495 cites W2145025818 @default.
- W2290754495 cites W2145349436 @default.
- W2290754495 cites W2152751713 @default.
- W2290754495 cites W2154097633 @default.
- W2290754495 cites W2163388487 @default.
- W2290754495 cites W2170006155 @default.
- W2290754495 cites W2181106711 @default.
- W2290754495 cites W4239149238 @default.
- W2290754495 doi "https://doi.org/10.1111/cei.12786" @default.
- W2290754495 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4872378" @default.
- W2290754495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26940143" @default.
- W2290754495 hasPublicationYear "2016" @default.
- W2290754495 type Work @default.
- W2290754495 sameAs 2290754495 @default.
- W2290754495 citedByCount "4" @default.
- W2290754495 countsByYear W22907544952017 @default.
- W2290754495 countsByYear W22907544952018 @default.
- W2290754495 countsByYear W22907544952020 @default.
- W2290754495 countsByYear W22907544952021 @default.
- W2290754495 crossrefType "journal-article" @default.
- W2290754495 hasAuthorship W2290754495A5013327092 @default.
- W2290754495 hasAuthorship W2290754495A5026694921 @default.
- W2290754495 hasAuthorship W2290754495A5069412319 @default.
- W2290754495 hasAuthorship W2290754495A5071366275 @default.
- W2290754495 hasAuthorship W2290754495A5073566037 @default.
- W2290754495 hasAuthorship W2290754495A5082237234 @default.
- W2290754495 hasBestOaLocation W22907544951 @default.
- W2290754495 hasConcept C104317684 @default.
- W2290754495 hasConcept C126322002 @default.
- W2290754495 hasConcept C135763542 @default.
- W2290754495 hasConcept C156957248 @default.
- W2290754495 hasConcept C180754005 @default.
- W2290754495 hasConcept C197754878 @default.
- W2290754495 hasConcept C203014093 @default.
- W2290754495 hasConcept C2778260677 @default.
- W2290754495 hasConcept C2779134260 @default.
- W2290754495 hasConcept C2780479503 @default.