Matches in SemOpenAlex for { <https://semopenalex.org/work/W2290812500> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2290812500 abstract "The serotonin 2A receptor (5-HT2AR) mediates the effects of hallucinogenic drugs such as DOI and LSD, as well as the neurotransmitter serotonin. Using mouse embryonic fibroblasts (MEFs) that lack βarrestins and mice that lack βarr2 (βarr2), we show that there is difference in signaling and trafficking of the 5-HT2AR that diverges at point of βarrestin interactions. In MEFs, DOI induces internalization and activates ERK1/2 in a βarrestin-independent manner, while serotonin requires βarrestins to internalize the receptor and to mediate most of the ERK1/2 activation. In WT frontal cortical neurons, the 5-HT2AR is intracellularly distributed; however in βarr2-KO neurons, the receptor is expressed on the cell surface. WT mice display a head twitch response when treated with hallucinogenic serotonergic agonists and the same response can be observed following high doses of the serotonin precursor, 5-hydroxytryptophan (5-HTP). βArr2-KO mice display head twitches in response to DOI but not to 5-HTP. Both 5-HTP and DOI treatments induce ERK1/2 activation in WT frontal cortex; however, only DOI activates ERK in βarr2-KO mice. Our findings demonstrate that 5-HT2AR activation by two distinct agonists diverges at the point of βarrestin interactions; in the absence of βarr2, differences between the behavioral responses to these drugs are revealed. NIDA funding: K01 DA14460 (LMB); F31 DA219532 (KMR)." @default.
- W2290812500 created "2016-06-24" @default.
- W2290812500 creator A5003815380 @default.
- W2290812500 creator A5030161632 @default.
- W2290812500 creator A5055663249 @default.
- W2290812500 date "2008-03-01" @default.
- W2290812500 modified "2023-09-23" @default.
- W2290812500 title "Ligand‐directed signaling of the serotonin 2A receptor depends on βarrestin‐2" @default.
- W2290812500 doi "https://doi.org/10.1096/fasebj.22.1_supplement.725.11" @default.
- W2290812500 hasPublicationYear "2008" @default.
- W2290812500 type Work @default.
- W2290812500 sameAs 2290812500 @default.
- W2290812500 citedByCount "0" @default.
- W2290812500 crossrefType "journal-article" @default.
- W2290812500 hasAuthorship W2290812500A5003815380 @default.
- W2290812500 hasAuthorship W2290812500A5030161632 @default.
- W2290812500 hasAuthorship W2290812500A5055663249 @default.
- W2290812500 hasConcept C126322002 @default.
- W2290812500 hasConcept C135285700 @default.
- W2290812500 hasConcept C139770010 @default.
- W2290812500 hasConcept C169760540 @default.
- W2290812500 hasConcept C170493617 @default.
- W2290812500 hasConcept C185592680 @default.
- W2290812500 hasConcept C2775864247 @default.
- W2290812500 hasConcept C2776219046 @default.
- W2290812500 hasConcept C2777503648 @default.
- W2290812500 hasConcept C37000724 @default.
- W2290812500 hasConcept C53910766 @default.
- W2290812500 hasConcept C55493867 @default.
- W2290812500 hasConcept C62478195 @default.
- W2290812500 hasConcept C71924100 @default.
- W2290812500 hasConcept C86803240 @default.
- W2290812500 hasConcept C95444343 @default.
- W2290812500 hasConcept C98274493 @default.
- W2290812500 hasConceptScore W2290812500C126322002 @default.
- W2290812500 hasConceptScore W2290812500C135285700 @default.
- W2290812500 hasConceptScore W2290812500C139770010 @default.
- W2290812500 hasConceptScore W2290812500C169760540 @default.
- W2290812500 hasConceptScore W2290812500C170493617 @default.
- W2290812500 hasConceptScore W2290812500C185592680 @default.
- W2290812500 hasConceptScore W2290812500C2775864247 @default.
- W2290812500 hasConceptScore W2290812500C2776219046 @default.
- W2290812500 hasConceptScore W2290812500C2777503648 @default.
- W2290812500 hasConceptScore W2290812500C37000724 @default.
- W2290812500 hasConceptScore W2290812500C53910766 @default.
- W2290812500 hasConceptScore W2290812500C55493867 @default.
- W2290812500 hasConceptScore W2290812500C62478195 @default.
- W2290812500 hasConceptScore W2290812500C71924100 @default.
- W2290812500 hasConceptScore W2290812500C86803240 @default.
- W2290812500 hasConceptScore W2290812500C95444343 @default.
- W2290812500 hasConceptScore W2290812500C98274493 @default.
- W2290812500 hasFunder F4320337347 @default.
- W2290812500 hasIssue "S1" @default.
- W2290812500 hasLocation W22908125001 @default.
- W2290812500 hasOpenAccess W2290812500 @default.
- W2290812500 hasPrimaryLocation W22908125001 @default.
- W2290812500 hasRelatedWork W1561144079 @default.
- W2290812500 hasRelatedWork W1984766700 @default.
- W2290812500 hasRelatedWork W1987096130 @default.
- W2290812500 hasRelatedWork W2056669820 @default.
- W2290812500 hasRelatedWork W2071884076 @default.
- W2290812500 hasRelatedWork W2077435495 @default.
- W2290812500 hasRelatedWork W2079846365 @default.
- W2290812500 hasRelatedWork W2290812500 @default.
- W2290812500 hasRelatedWork W45431150 @default.
- W2290812500 hasRelatedWork W946318013 @default.
- W2290812500 hasVolume "22" @default.
- W2290812500 isParatext "false" @default.
- W2290812500 isRetracted "false" @default.
- W2290812500 magId "2290812500" @default.
- W2290812500 workType "article" @default.