FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2290871389> ?p ?o ?g. }

• W2290871389 endingPage "286" @default.
• W2290871389 startingPage "277" @default.
• W2290871389 abstract "Histamine, an important modulator of the arousal states of the central nervous system, has been reported to contribute an excitatory drive at the hypoglossal motor nucleus to the genioglossus (GG) muscle, which is involved in the pathogenesis of obstructive sleep apnea. However, the effect of histamine on hypoglossal motoneurons (HMNs) and the underlying signaling mechanisms have remained elusive. Here, whole-cell patch-clamp recordings were conducted using neonatal rat brain sections, which showed that histamine excited HMNs with an inward current under voltage-clamp and a depolarization membrane potential under current-clamp via histamine H1 receptors (H1Rs). The phospholipase C inhibitor U-73122 blocked H1Rs-mediated excitatory effects, but protein kinase A inhibitor and protein kinase C inhibitor did not, indicating that the signal transduction cascades underlying the excitatory action of histamine on HMNs were H1R/Gq/11 /phospholipase C/inositol-1,4,5-trisphosphate (IP3). The effects of histamine were also dependent on extracellular Na(+) and intracellular Ca(2+), which took place via activation of Na(+)-Ca(2+) exchangers. These results identify the signaling molecules associated with the regulatory effect of histamine on HMNs. The findings of this study may provide new insights into therapeutic approaches in obstructive sleep apnea. We proposed the post-synaptic mechanisms underlying the modulation effect of histamine on hypoglossal motoneuron. Histamine activates the H1Rs via PLC and IP3, increases Ca(2+) releases from intracellular stores, promotes Na(+) influx and Ca(2+) efflux via the NCXs, and then produces an inward current and depolarizes the neurons. Histamine modulates the excitability of HMNs with other neuromodulators, such as noradrenaline, serotonin and orexin. We think that these findings should provide an important new direction for drug development for the treatment of obstructive sleep apnea." @default.
• W2290871389 created "2016-06-24" @default.
• W2290871389 creator A5014969873 @default.
• W2290871389 creator A5025461362 @default.
• W2290871389 creator A5029484872 @default.
• W2290871389 creator A5032161254 @default.
• W2290871389 creator A5042514704 @default.
• W2290871389 creator A5051670067 @default.
• W2290871389 creator A5054235625 @default.
• W2290871389 date "2016-03-01" @default.
• W2290871389 modified "2023-10-18" @default.
• W2290871389 title "Signaling mechanism underlying the histamine-modulated action of hypoglossal motoneurons" @default.
• W2290871389 cites W1576850329 @default.
• W2290871389 cites W1595533287 @default.
• W2290871389 cites W170103974 @default.
• W2290871389 cites W1703861757 @default.
• W2290871389 cites W1917933986 @default.
• W2290871389 cites W1977407849 @default.
• W2290871389 cites W1978623496 @default.
• W2290871389 cites W1987591990 @default.
• W2290871389 cites W1993481471 @default.
• W2290871389 cites W1996958452 @default.
• W2290871389 cites W2000314686 @default.
• W2290871389 cites W2011594770 @default.
• W2290871389 cites W2017063807 @default.
• W2290871389 cites W2022628868 @default.
• W2290871389 cites W2024524548 @default.
• W2290871389 cites W2041922823 @default.
• W2290871389 cites W2042050086 @default.
• W2290871389 cites W2052661689 @default.
• W2290871389 cites W2058159881 @default.
• W2290871389 cites W2059476384 @default.
• W2290871389 cites W2072640381 @default.
• W2290871389 cites W2080830076 @default.
• W2290871389 cites W2080865965 @default.
• W2290871389 cites W2083868422 @default.
• W2290871389 cites W2085192229 @default.
• W2290871389 cites W2090464321 @default.
• W2290871389 cites W2094211651 @default.
• W2290871389 cites W2123035658 @default.
• W2290871389 cites W2124052130 @default.
• W2290871389 cites W2126938901 @default.
• W2290871389 cites W2127398647 @default.
• W2290871389 cites W2129259968 @default.
• W2290871389 cites W2140462488 @default.
• W2290871389 cites W2145451287 @default.
• W2290871389 cites W2160414529 @default.
• W2290871389 cites W2163742294 @default.
• W2290871389 cites W2172090998 @default.
• W2290871389 cites W2335815721 @default.
• W2290871389 cites W2398491216 @default.
• W2290871389 cites W45657630 @default.
• W2290871389 doi "https://doi.org/10.1111/jnc.13548" @default.
• W2290871389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26811198" @default.
• W2290871389 hasPublicationYear "2016" @default.
• W2290871389 type Work @default.
• W2290871389 sameAs 2290871389 @default.
• W2290871389 citedByCount "10" @default.
• W2290871389 countsByYear W22908713892017 @default.
• W2290871389 countsByYear W22908713892020 @default.
• W2290871389 countsByYear W22908713892022 @default.
• W2290871389 countsByYear W22908713892023 @default.
• W2290871389 crossrefType "journal-article" @default.
• W2290871389 hasAuthorship W2290871389A5014969873 @default.
• W2290871389 hasAuthorship W2290871389A5025461362 @default.
• W2290871389 hasAuthorship W2290871389A5029484872 @default.
• W2290871389 hasAuthorship W2290871389A5032161254 @default.
• W2290871389 hasAuthorship W2290871389A5042514704 @default.
• W2290871389 hasAuthorship W2290871389A5051670067 @default.
• W2290871389 hasAuthorship W2290871389A5054235625 @default.
• W2290871389 hasBestOaLocation W22908713891 @default.
• W2290871389 hasConcept C1122143 @default.
• W2290871389 hasConcept C112592302 @default.
• W2290871389 hasConcept C126322002 @default.
• W2290871389 hasConcept C134018914 @default.
• W2290871389 hasConcept C169760540 @default.
• W2290871389 hasConcept C17077164 @default.
• W2290871389 hasConcept C185592680 @default.
• W2290871389 hasConcept C2778597717 @default.
• W2290871389 hasConcept C2781333164 @default.
• W2290871389 hasConcept C529278444 @default.
• W2290871389 hasConcept C62478195 @default.
• W2290871389 hasConcept C71924100 @default.
• W2290871389 hasConcept C86803240 @default.
• W2290871389 hasConcept C95444343 @default.
• W2290871389 hasConceptScore W2290871389C1122143 @default.
• W2290871389 hasConceptScore W2290871389C112592302 @default.
• W2290871389 hasConceptScore W2290871389C126322002 @default.
• W2290871389 hasConceptScore W2290871389C134018914 @default.
• W2290871389 hasConceptScore W2290871389C169760540 @default.
• W2290871389 hasConceptScore W2290871389C17077164 @default.
• W2290871389 hasConceptScore W2290871389C185592680 @default.
• W2290871389 hasConceptScore W2290871389C2778597717 @default.
• W2290871389 hasConceptScore W2290871389C2781333164 @default.
• W2290871389 hasConceptScore W2290871389C529278444 @default.
• W2290871389 hasConceptScore W2290871389C62478195 @default.
• W2290871389 hasConceptScore W2290871389C71924100 @default.
• W2290871389 hasConceptScore W2290871389C86803240 @default.

• next